Department of Immunology,
Graduate School of Biomedical and Health Sciences

業績

PUBLICATIONS

2021

1. Yasuda, T. et al., Generation and characterization of CD19‐iCre mice as a tool for efficient and specific conditional gene targeting in B cells. Sci. Rep., 11, 5524, 2021.

2. Huang, S. and Yasuda, T. Pathologically Relevant Mouse Models for Epstein–Barr Virus–Associated B Cell Lymphoma. Front. Immunol., 12, 639844, 2021.

3. Sakurai, T. et al., A conserved PI(4,5)P2-binding domain is critical for immune regulatory function of DOCK8. Life Sci. Alliance, 4(4):e202000873, 2021.

2020

4. Sommermann, T., Yasuda, T., Ronen, J., Wirtz, T., Weber, T., Sack, U., Caeser, R., Zhang, J., Li, X., Chu, V. T., Jauch, A., Unger, K., Hodson, D. J., Akalin, A., and Rajewsky, K. Functional Interplay of Epstein-Barr virus oncoproteins in a mouse model of B cell lymphomagenesis. Proc. Natl. Acad. Sci. U. S. A., doi: 10.1073/pnas.1921139117, 2020.

5. Yang Y, Nagai S, Kang S, Xia Y, Kawano Y, Miyake K, Karasuyama H, Azuma M. Tolerogenic properties of CD206+ macrophages appeared in the sublingual mucosaafter repeated antigen-painting. Int Immunol. doi:10.1093/intimm/dxaa014, 2020

6. Sukegawa K, Shitaoka K, Hamana H, Kobayashi E, Miyahara Y, Fujii K, Tsuda K, Saeki S, Nagata T, Ozawa T, Saito Shigeru, Fujii T, Muraguchi A, Kishi. Relationship between T cell receptor clonotype and PD‐1 expression of tumor‐infiltrating lymphocytes in colorectal cancer. European Journal of Immunology. 22 May 2020.

7.Furukawa, M., Ohki, S., Kitanobo, S., Fukami, H. & Morita, M. “Differences in spawning time drive cryptic speciation in the coral Acropora divaricata.” Marine Biology, 167(11), 1-10. 2020.

2019

8.Imami, K. and Yasuda, T. Measuring protein synthesis during cell cycle by Azidohomoalanine (AHA) labeling and flow cytometric analysis. Bio Protocol, 9, Iss 8, 2019.

9.Yoshikawa S, Oh-Hora M, Hashimoto R, Nagao T, Peters L, Egawa M, Ohta T, Miyake K, Adachi T, Kawano Y, Yamanishi Y, Karasuyama H. Pivotal role of STIM2, but not STIM1, in IL-4 production by IL-3-stimulated murine basophils. Science signaling. 12 (576), 2019

10.Nagao T, Yamanishi Y, Miyake K, Teranishi M, Takahashi S, Yoshikawa S, Kawano Y, Karasuyama H. Aggregation makes a protein allergenic at the challenge phase of basophil-mediated allergy in mice. Int Immunol. 31(1):41-49, 2019.

11.Kawahara, T., Tezuka, J., Ninomiya, T., Honjo, S., Masumoto, N., Nanishi, M., Nakayama, H., and Ohga, S. Risk prediction of severe reaction to oral challenge test of cow's milk. Eur. J. Pediatr. 178, 181-188, 2019.

12.Sato, M., Hosoya, S., Yoshikawa, S., Ohki, S., Kobayashi, Y., Itou, T., & Kikuchi, K. “A highly flexible and repeatable genotyping method for aquaculture studies based on target amplicon sequencing using next-generation sequencing technology.” Scientific reports, 9(1): 6904. 2019.

2018

13. Imami, K., Milek, M., Bogdanow, B., Yasuda, T., Kastelic, N., Zauber, H., Ishihama, Y., Landthaler, M., and Selbach, M. Phosphorylation of the ribosomal protein RPL12/uL11 affects translation during mitosis. Mol. Cell, 72, 84-98, 2018.

14. Karasuyama H, Miyake K, Yoshikawa S, Kawano Y, Yamanishi Y. How do basophils contribute to Th2 cell differentiation and allergic responses? Int Immunol. 30;30(9):391-396, 2018.

15. Tabakawa Y, Ohta T, Yoshikawa S, Robinson EJ, Yamaji K, Ishiwata K, Kawano Y, Miyake K, Yamanishi Y, Ohtsu H, Adachi T, Watanabe N, Kanuka H, Karasuyama H. Histamine Released From Skin-Infiltrating Basophils but Not Mast Cells Is Crucial for Acquired Tick Resistance in Mice. Front Immunol. 3;9:1540, 2018.

16. Kawano Y, Petkau G, Stehle C, Durek P, Heinz GA, Tanimoto K, Karasuyama H, Mashreghi MF, Romagnani C, Melchers F. Stable lines and clones of long-term proliferating normal, genetically unmodified murine common lymphoid progenitors. Blood. 131(18):2026-2035, 2018.

17. Petkau G, Kawano Y, Wolf I, Knoll M, Melchers F. MiR221 promotes precursor B-cell retention in the bone marrow by amplifying the PI3K-signaling pathway in mice. Eur J Immunol. 48(6)975-989, 2018.

18. Ho, V.M., Hirohashi, N., Kong, W.S., Guo, Y., Ota, K., Itai, J., Yamaga, S., Suzuki, K., Tanigawa, K., Kanno, M., and Shime, N. Sera from septic patients contain the inhibiting activity of the extracellular ATP-dependent inflammasome pathway. Tohoku J. Exp. Med. 245, 193-204, 2018.

19. Kawahara, T., Masumoto, N., and Tezuka, J. Risk factors for severe reactions in a low-dose oral food challenge in cow's milk. Nihon Shoni Arerugi Gakkaishi. 32, 647-653, 2018.

20. Shitaoka K, Hamana H, Kishi H, Hayakawa Y, Kobayashi E, Sukegawa K, Piao X, Lyu F, Nagata T, Sugiyama D, Nishikawa H, Tanemura A, Katayama I, Murahashi M, Takamatsu Y, Tani K, Ozawa T, Muraguchi A. Identification of tumoricidal TCRs from tumor-infiltrating lymphocytes by single-cell analysis. Cancer Immunol Res. Feb 23 2018.

21. Ohki, S., Hagi, T., Nakano, K., Shiroma, A., Tamotsu, H., Shimoji, M., Shinzato, M., Ashimine, N., Minami, M., Nakanishi, T., Teruya, K., Satou, K., Moriya, N., Kobayashi, M., Nomura, M., Suzuki, C., & Hirano, T. “Complete Genome Sequence of Carotenoid-Producing Enterococcus gilvus CR1, Isolated from Raw Cow’s Milk.” Microbiol Resour Announc, 7(10): e00988-18. 2018.

22. Moriya, N., Nakan0, K., Shiroma, A., Shinzato, M., Ashimine, N., Minami, M., Tamotsu, H.,Shimoji, M., Nakanishi, T., Ohki, S., Teruya, K., Satou, K., Hirano, T., Hagi, T., Kobayashi, M., Nomura, M., Kimoto-Nira, H., Tajima, K., Cai, Y., & Suzuki, C. “Complete Genome Sequence of Lactobacillus plantarum Strain LQ80, Selected for Preparation of Fermented Liquid Feed for Pigs.” Genome announcements, 6(25): e00530-18. 2018.

23. Asahina, Y., Shiroma, A., Nakano, K., Tamotsu, H., Ashimine, N., Shinzato, M., Minami, M., Shimoji, M., Nakanishi, T., Ohki, S., Teruya, K., Satou, K., Kobayashi, M., Hagi, T., Moriya, N., Suzuki, C., Tajima, A., Nomura, M., & Hirano, T. “Complete Genome Sequence of Lactobacillus paracasei EG9, a Strain Accelerating Free Amino Acid Production during Cheese Ripening.” Genome announcements, 6(27), e00627-18. 2018.

24. Ikegami, K., Aita, Y., Shiroma, A., Shimoji, M., Tamotsu, H., Ashimine, N., Shinzato, M., Ohki, S., Nakano, K., Teruya, K., Satou, K., Hirano, T., & Yohda, M. “Complete Genome Sequence of Petrimonas sp. Strain IBARAKI, Assembled from the Metagenome Data of a Culture Containing Dehalococcoides spp.” Genome announcements: 6(18), e00384-18. 2018.

25. Nakano, K., Minami, M., Shinzato, M., Shimoji, M., Ashimine, N., Shiroma, A., Ohki, S., Nakanishi, T., Tamotsu, H., Teruya, K., Satou, K., Moriya, N., Kimoto-Nira, H., Kobayashi, M., Hagi, T., Nomura, M., Suzuki, C., & Hirano, T. “Complete Genome Sequence of Lactococcus lactis subsp. lactis G50 with Immunostimulating Activity, Isolated from Napier Grass.” Genome announcements, 6(8): e00069-18. 2018.

2017

26.Ohta T, Yoshikawa S, Tabakawa Y, Yamaji K, Ishiwata K, Shitara H, Taya C, Oh-Hora M, Kawano Y, Miyake K, Yamanishi Y, Yonekawa H, Watanabe N, Kanuka H, Karasuyama H. Skin CD4+ Memory T Cells Play an Essential Role in Acquired Anti-Tick Immunity through Interleukin-3-Mediated Basophil Recruitment to Tick-Feeding Sites. Front Immunol.8:1348, 2017.

27.Tornack J, Kawano Y, Garbi N, Hämmerling GJ, Melchers F, Tsuneto M. Flt3 ligand-eGFP-reporter expression characterizes functionally distinct subpopulations of CD150+long-term repopulating murine hematopoietic stem cells. Eur J Immunol. 47(9):1477-148, 2017

28.Kawano Y, Petkau G, Wolf I, Tornack J and Melchers F. IL-7 and immobilized Kit-ligand stimulate serum- and stromal cell-free cultures of precursor B-cell lines and clones. Eur J Immunol. 47, 206-212, 2017.

29.Nakano, K., Shiroma, A., Shimoji, M., Tamotsu, H., Ashimine, N., Ohki, S., Shinzato, M., Minami, M., Nakanishi, T., Teruya, K., Satou, K., & Hirano, T. “Advantages of genome sequencing by long-read sequencer using SMRT technology in medical area.” Human Cell, Springer Japan, 30: 149-161. 2017.

30.Yohda, M., Ikegami, K., Aita, Y., Kitajima, M., Takechi, A., Iwamoto, M., Fukuda, T., Tamura, N., Shibasaki, J., Koike, S., Komatsu, D., Miyagi, S., Nishimura, M., Uchino, Y., Shiroma, A., Shimoji, M., Tamotsu, H., Ashimine, N., Shinzato, M., Ohki, S., Nakano, K., Teruya, K., Satou, K., Hirano, T., & Yagi, O. “Isolation and genomic characterization of a Dehalococcoides strain suggests genomic rearrangement during culture.” Scientific reports, 7(1): 2230. 2017.

2016

31.Wirtz, T., Weber, T., Kracker, S., Sommermann, T., Rajewsky, K., and Yasuda, T. A mouse model for acute Epstein-Barr virus infection. Proc. Natl. Acad. Sci. U. S. A., 113, 13821-13826, 2016.

32.Ishikawa, E., Kosako, H., Yasuda, T., Kurosaki, T., Saito, T., and Yamasaki, S. Protein kinase D regulates positive selection of CD4+ thymocytes through phosphorylation of SHP-1. Nat. Commun., 7, 12756, 2016.

33.Shinohara, H., Yasuda, T., and Kurosaki, T. TAK1 adaptor proteins, TAB2 and TAB3, link the signalosome to B-cell receptor-induced IKK activation. FEBS Lett., 590, 3264-3269, 2016.

34.Derudder, E., Herzog, S., Labi, V., Yasuda, T., Köchert, K., Janz, M., Villunger, A., Schmidt-Supprian, M., and Rajewsky, K. Canonical NF-κB signaling is uniquely required for the long-term persistence of functional mature B cells. Proc. Natl. Acad. Sci. U. S. A., 113, 5065-5070, 2016.

35.Cho, S.*, Wu, C.J.*, Yasuda, T.*, Cruz, L.O., Khan, A.A., Lin, L.L., Nguyen, D.T., Miller, M., Lee, H.M., Kuo, M.L., Broide, D.H., Rajewsky, K., Rudensky, A.Y., and Lu, L.F. miR23~27~24 clusters control effector T cell differentiation and function. J. Exp. Med., 213, 235-249, 2016. (*Equal contribution)

36.Kanno, M., Kong, W.S., Inoue, H., Shimojo, N., Tsuyama, N., Arita, M., and Guo, Y. Identification of DAMPs molecules in mother's milk of a cohort study on atopic dermatitis in breastfed infants: Mouse model study and correlation with gut ILCs. Eur. J. Immunol. 46, 2016.

37.Piao X, Osawa T, Hamana H, Shitaoka K, Jin A, Kishi H, Muraguti A. TRAIL-receptor 1 IgM antibodies strongly induce apoptosis in human cancer cells in vitro and in vivo. OncoImmunology. Published online: 04 May 2016.

38.Hamana H, Shitaoka K, Kishi H, Ozawa T, Muraguchi A. A novel, rapid and efficient method of cloning functional antigen-specific T-cell receptors from single human and mouse T-cells. Biochemical and Biophysical Research Communications (BBRC). 2016 Jun 10;474(4):709-14.

39.Nakano, K., Shiroma, A., Tamotsu, H., Ohki, S., Shimoji, M., Ashimine, N., Shinzato, M., Minami, M., Nakanishi, T., Teruya, K., Satou, K., Suzuki, C., Kimoto-Nira, H., Kobayashi, M., Mizumachi, K., Aoki, R., Miyata, S., Yamamoto, K., Ohtake, Y., Eguchi-Ogawa, T., Moriya, N., Hagi, T., Nomura, M., & Hirano, T. “First Complete Genome Sequence of the Skin-Improving Lactobacillus curvatus Strain FBA2, Isolated from Fermented Vegetables, Determined by PacBio Single-Molecule Real-Time Technology.” Genome announcements, 4(5), e00884-16. 2016.

2015

40.Shinohara, H., Behar, M., Inoue, K., Hiroshima, M., Yasuda, T., Nagashima, T., Kimura, S., Sanjo, H., Maeda, S., Yumoto, N., Ki, S., Akira, S., Sako, Y., Hoffmann, A., Kurosaki, T., and Okada-Hatakeyama, M. Positive feedback within a kinase signaling complex functions as a swit Sander, S., Chu, V.T., Yasuda, T., Franklin, A., Graf, R., Calado, D.P., Li, S., Imami, K., Selbach, M., Di Virgilio, M., Bullinger, L., and Rajewsky, K. PI3 Kinase and FOXO1 transcription factor activity differentially control B cells in the germinal center light and dark zone. Immunity, 43, 1075-1086, 2015.

41.Murakaly regulates A20 mRNA and modulates the activity of the IKK/NF-κB pathway. Nat. Commun., 6:7367, 2015.

42.LiHua L, Yoshikawa S, Ohta T, Horiguchi K, Kawano Y, Ohtsu H, Yamanishi Y, Karasuyama H. Large particulate allergens can elicit mast cell-mediated anaphylaxis without exit from blood vessels as efficiently as do small soluble allergens. Biochem Biophys Res Commun. 6;467(1):70-5, 2015.

43.Mokuda, S., Miyazaki, T., Ito, Y., Yamasaki, S., Inoue, H., Guo, Y., Kong, W.S., Kanno, M., Takasugi, K., Sugiyama, E., and Masumoto, J. The protwa, Y., Hinz, M., Mothes, J., Schuetz, A., Uhl, M., Wyler, E., Yasuda, T., Mastrobuoni, G., Friedel, C., Dölken, L., Kempa, S., Schmidt-Supprian, M., Blüthgen, N., Backofen, R., Heinemann, U., Wolf, J., Scheidereit, C., and Landthaler, M. RC3H1 posttranscriptionalo-oncogene survivin splice variant 2B is induced by PDGF and leads to cell proliferation in rheumatoid arthritis fibroblast-like synoviocytes. Sci. Rep., 5:9795, 2015.

44.Kishi H, Hamana H, Shitaoka K, Muraguchi A. Identification of tumor-specific T cell receptors from primary tumor-infiltrating lymphocytes. J Immunother Cancer. ,2015; 3(Suppl 2): P74. Published online 2015 Nov 4.

45.Ohki, S., Kowalski, R. K., Kitanobo, S., & Morita, M. “Changes in spawning time led to the speciation of the broadcast spawning corals Acropora digitifera and the cryptic species Acropora sp. 1 with similar gamete recognition systems.” Coral reefs, 34: 1189-1198. 2015.

46.Nakano, K., Terabayashi, Y., Shiroma, A., Shimoji, M., Tamotsu, H., Ashimine, N., Ohki, S., Shinzato, M., Teruya, K., Satou, K., & Hirano, T. “First complete genome sequence of Clostridium sporogenes DSM 795T, a nontoxigenic surrogate for Clostridium botulinum, determined using PacBio single-molecule real-time technology.” Genome announcements, 3(4): e00832-15. 2015.

47.Satou, K., Shimoji, M., Tamotsu, H., Juan, A., Ashimine, N., Shinzato, M., Toma, C., Nohara, T., Shiroma, A., Nakano, K., Teruya, K., Terabayashi, Y., Ohki, S., Koizumi, N., Okano, S., Suzuki, T., & Hirano, T. “Complete Genome Sequences of Low-Passage Virulent and High-Passage Avirulent Variants of Pathogenic Leptospira interrogans Serovar Manilae Strain UP-MMC-NIID, Originally Isolated from a Patient with Severe Leptospirosis, Determined Using PacBio Single-Molecule Real-Time Technology.” Genome announcements, 3(4): e00882-15. 2015.

48.Shiroma, A., Terabayashi, Y., Nakano, K., Shimoji, M., Tamotsu, H., Ashimine, N., Ohki, S., Shinzato, M., Teruya, K., Satou, K., & Hirano, T. “First complete genome sequences of Staphylococcus aureus subsp. aureus Rosenbach 1884 (DSM 20231T), determined by PacBio single-molecule real-time technology.” Genome announcements, 3(4): e00800-15. 2015.

49. Nakano, K., Terabayashi, Y., Shiroma, A., Shimoji, M., Tamotsu, H., Ashimine, N., Ohki, S., Shinzato, M., Teruya, K., Satou, K., & Hirano, T. “First complete genome sequence of Pseudomonas aeruginosa (Schroeter 1872) Migula 1900 (DSM 50071T), determined using PacBio single-molecule real-time technology.” Genome announcements, 3(4): e00932-15. 2015.

1997-2014

50.Yasukawa, S., Miyazaki, Y., Yoshii, C., Nakaya, M., Ozaki, N., Toda, S., Kuroda, E., Ishibashi, K., Yasuda, T., Natsuaki, Y., Mi-ichi, F., Iizasa, E., Nakahara, T., Yamazaki, M., Kabashima, K., Iwakura, Y., Takai, T., Saito, T., Kurosaki, T., Malissen, B., Ohno, N., Furue, M., Yoshida, H., and Hara, H. An ITAM-Syk-CARD9 signaling axis triggers contact hypersensitivity by stimulating IL-1 production in dendritic cells. Nat. Commun., 5:3755, 2014.

51.Shinohara, H., Behar, M., Inoue, K., Hiroshima, M., Yasuda, T., Nagashima, T., Kimura, S., Sanjo, H., Maeda, S., Yumoto, N., Ki, S., Akira, S., Sako, Y., Hoffmann, A., Kurosaki, T., and Okada-Hatakeyama, M. Positive feedback within a kinase signaling complex functions as a switch mechanism for NF-κB activation. Science, 344, 760-764, 2014.

52.Ohki, S., Morita, M., Kitanobo, S., Kowalska, A. A., & Kowalski, R. K. “Cryopreservation of Acropora digitifera sperm with use of sucrose and methanol based solution.” Cryobiology, 69: 134-139. 2014.

53.Yasuda, T.*, Wirtz, T., Zhang, B., Wunderlich, T., Schmidt-Supprian, M., Sommermann, T., and Rajewsky, K. Studying Epstein-Barr-Virus pathologies and immune surveillance by reconstructing EBV infection in mice. Cold Spring Harbor Symposia on Quantitative Biology, Immunity and Tolerance, 78, 020222, 2013. (*Corresponding author)

54.Obata-Ninomiya K, Ishiwata K, Tsutsui H, Nei Y, Yoshikawa S, Kawano Y, Minegishi Y, Ohta N, Watanabe N, Kanuka H, Karasuyama H. The skin is an important bulwark of acquired immunity against intestinal helminths. J Exp Med.,210(12):2583-95, 2013.

55.Egawa, M., Mukai, K., Yoshikawa, S, Iki, M., Mukaida, N., Kawano, Y., Minegishi, Y., and Karasuyama, H.: Inflammatory monocytes recruited to allergic skin acquire an anti-inflammatory M2 phenotype via basophil-derived interleukin-4. Immunity. 38: 570–580, 2013.

56.Ohki, S., Irie, T., Inoue, M., Shinmen, K., Kawahata, H., Nakamura, T., Kato, A., Nojiri, Y., Suzuki, A., Sakai, K., & van Woesik, R. “Calcification responses of symbiotic and aposymbiotic corals to near-future levels of ocean acidification.” Biogeosciences, 10: 6807-6814. 2013.

57.Ohki, S., Irie, T., Inoue, M., Shinmen, K., Kawahata, H., Nakamura, T., Kato, A., Nojiri, Y., Suzuki, A., Sakai, K., & van Woesik, R. “Symbiosis increases coral tolerance to ocean acidification.” Biogeosciences Discussions, 10: 7013-7030. 2013.

58.Zhang, B.*, Kracker, S.*, Yasuda, T.*, Casola, S.*, Vanneman, M., Hömig-Hölzel, C., Wang, Z., Derudder, E., Li, S., Chakraborty, T., Cotter, S. E., Koyoma, S., Currie, T., Freeman, G.J., Kutok, J. L., Rodig, S. J., Dranoff, G., and Rajewsky, K. Immune surveillance and therapy of lymphomas driven by Epstein-Barr virus protein LMP1 in a mouse model. Cell, 148, 739-751, 2012. (*Equal contribution)

59.Kawano, Y., Ouchida, R., Wang, J-Y, Yoshikawa, S. Yamamoto, M., Kitamura, D., and Karasuyama, H.: A novel mechanism for the autonomous termination of pre-B cell receptor expression via induction of lysosomal-associated protein transmembrane 5. Mol. Cell. Biol. 32: 4462-71, 2012.

60.Ogawa, H., Mukai, K., Kawano, Y., Minegishi, Y., and Karasuyama, H.: Th2-inducing cytokines IL-4 and IL-33 synergistically elicit the expression of transmembrane TNF-a on macrophages through the autocrine action of IL-6. Biochem. Biophys. Res. Commun. 420: 114-118, 2012.

61.Kurogi, T., Inoue, H., Guo, Y., Nobukiyo, A., Nohara, K., and Kanno, M. A methyl-deficient diet modifies early B cell development. Pathobiology, 79, 209-218, 2012.

62.Yasuda, T., Kometani, K., Takahashi, N., Imai, Y., Aiba, A., and Kurosaki, T. ERKs induce expression of the transcriptional repressor Blimp-1 and subsequent plasma cell differentiation. Science Signaling, 4, ra25, 2011.

63.Yamagishi, H., Mochizuki, Y., Hamakubo, T., Obata, K., Ugajin, T., Sato, S., ff., Minegishi, Y., and Karasuyama, H .:Basophil-derived mouse mast cell protease 11 induces microvascular leakage and tissue edema in a mast cell-independent manner. Biochem. Biophys. Res. Commun .415: 709-713, 2011.

64.Nishikado, H., Mukai, K., Kawano, Y., Minegishi, Y., and Karasuyama, H : NK cell-depleting anti-asialo GM1 Ab exhibits a lethal ‘off-target' effect on basophils in vivo . J. Immunol .186: 5766-5771, 2011.

65.Guo, Y., Miyazaki, M., Itoi, M., Satoh, R., Iwama, A., Amagai, T., Kawamoto, H., and Kanno, M. Polycomb group gene Bmi1 plays a role in the growth of thymic epithelial cells. Eur. J. Immunol., 41, 1098-1107, 2011.

66.Nakamura, M., Ohki, S., Suzuki, A., & Sakai, K. “Coral Larvae under Ocean Acidification: Survival, Metabolism, and Metamorphosis.” PLoS ONE, 6: e14521. 2011.

67.Kuchen, S., Resch, W., Yamane, A., Kuo, N., Li, Z., Chakraborty, T., Wei, L., Laurence, A., Yasuda, T., Peng, S., Hu-Li, J., Lu, K., Dubois, W., Kitamura, Y., Charles, N., Sun, H.W., Muljo, S., Schwartzberg, P.L., Paul, W.E., O’Shea, J., Rajewsky, K., and Casellas, R. Regulation of microRNA expression and abundance during lymphopoiesis. Immunity, 32, 828-839, 2010.

68.Wada T, Ishiwata K, Koseki H, Ishikura T, Ugajin T, Ohnuma N, Obata K, Ishikawa R, Yoshikawa S, Mukai K, Kawano Y, Minegishi Y, Yokozeki H, Watanabe N, Karasuyama H. Selective ablation of basophils in mice reveals their nonredundant role in acquired immunity against ticks. J Clin Invest. 120(8):2867-75, 2010

69.Ishikawa R, Tsujimura Y, Obata K, Kawano Y, Minegishi Y, Karasuyama H. IgG-mediated systemic anaphylaxis to protein antigen can be induced even under conditions of limited amounts of antibody and antigen. Biochem Biophys Res Commun. 402(4):742-6, 2010

70.Miyazaki, K., Miyazaki, M., Guo, Y., Yamasaki, N., Kanno, M., Honda, Z., Oda, H., Kawamoto, H., and Honda, H. The role of the basic helix-loop-helix transcription factor Dec1 in the regulatory T cells. J. Immunol., 185, 7330-7339, 2010.

71.Ugajin T, Kojima T, Mukai K, Obata K, Kawano Y, Minegishi Y, Eishi Y, Yokozeki H, Karasuyama H. Basophils preferentially express mouse Mast Cell Protease 11 among the mast cell tryptase family in contrast to mast cells. J Leukoc Biol. (6):1417-25, 2009

72.Yoshikawa S, Kawano Y, Minegishi Y, Karasuyama H. The skewed heavy-chain repertoire in peritoneal B-1 cells is predetermined by the selection via pre-B cell receptor during B cell ontogeny in the fetal liver. Int Immunol. (1):43-52, 2009

73.Yasuda, T. and Kurosaki, T. Regulation of lymphocyte fate by Ras/ERK signals. Cell Cycle, 7, 3634-3640, 2008.

74.Yasuda, T., Sanjo, H., Pagès, G., Kawano, Y., Karasuyama, H., Pouysségur, J., Ogata, M., and Kurosaki, T. Erk kinases link pre-BCR signaling to transcriptional events required for early B cell expansion. Immunity, 28, 499-508, 2008.

75.Hosooka, T., Noguchi, T., Kotani, K., Nakamura, T., Sakaue, H., Inoue, H., Ogawa, W., Tobimatsu, K., Takazawa, K., Sakai, M., Matsuki, Y., Hiramatsu, R., Yasuda, T., Lazar, M.A., Yamanashi, Y., and Kasuga, M. Dok-1 mediates high-fat diet-induced adipocyte hypertrophy and obesity through modulation of PPARγ phosphorylation. Nature Med., 14, 188-193, 2008.

76.Tsujimura Y, Obata K, Mukai K, Shindou H, Yoshida M, Nishikado H, Kawano Y, Minegishi Y, Shimizu T, Karasuyama H. Basophils play a pivotal role in immunoglobulin-G-mediated but not immunoglobulin-E-mediated systemic anaphylaxis. Immunity. (4):581-9, 2008

77.Miyazaki, M., Miyazaki, K., Itoi, M., Katoh, Y., Guo, Y., Kanno, R., Katoh-Fukui, Y., Honda, H., Amagai, T., van Lohuizen, M., Kawamoto, H., and Kanno, M. Thymocyte proliferation induced by pre-T cell receptor signaling is maintained through polycomb gene product Bmi-1-mediated Cdkn2a repression. Immunity, 28, 231-245, 2008.

78.Inoue, A.*, Yasuda, T.*, Yamamoto, T., and Yamanashi, Y. Dok-1 is a positive regulator of IL-4 signalling and IgE response. J. Biochem., 142, 257-263, 2007. (*Equal contribution)

79.Yasuda, T., Bundo, K., Hino, A., Honda, K., Inoue, A., Shirakata, M., Osawa, M., Tamura, T., Nariuchi, H., Oda, H., Yamamoto T., and Yamanashi, Y. Dok-1 and Dok-2 are negative regulators of T cell receptor signaling. Int. Immunol., 19, 487-495, 2007.

80.Matsubara, Y., Kawasaki, I., Urushiyama, S., Yasuda, T., Shirakata, M., Iino, Y., Shibuya, H., and Yamanashi, Y. The adaptor-like protein ROG-1 is required for activation of the Ras-MAP kinase pathway and meiotic cell cycle progression in Caenorhabditis elegans. Genes Cells, 12, 407-420, 2007.

81.Obata K, Mukai K, Tsujimura Y, Ishiwata K, Kawano Y, Minegishi Y, Watanabe N, Karasuyama H. Basophils are essential initiators of a novel type of chronic allergic inflammation. Blood. 110(3):913-20, 2007.

82.Honma, M., Higuchi, O., Shirakata, M., Yasuda, T., Shibuya, H., Iemura, S., Natsume, T., and Yamanashi, Y. Dok-3 sequesters Grb2 and inhibits the Ras-Erk pathway downstream of protein-tyrosine kinases. Genes Cells, 11, 143-151, 2006.

83.Yamamoto M, Hayashi K, Nojima T, Matsuzaki Y, Kawano Y, Karasuyama H, Goitsuka R, Kitamura D. BASH-novel PKC-Raf-1 pathway of pre-BCR signaling induces kappa gene rearrangement. Blood. 108(8):2703-11, 2006

84.Kawano Y, Yoshikawa S, Minegishi Y, Karasuyama H. Pre-B cell receptor assesses the quality of IgH chains and tunes the pre-B cell repertoire by delivering differential signals.  J. Immunol. 177(4):2242-2249, 2006

85.Shinohara, H., Yasuda, T., Aiba, Y., Sanjo, H., Hamadate, M., Watarai, H., Sakurai, H., and Kurosaki, T. PKCβ regulates BCR-mediated IKK activation by facilitating the interaction between TAK1 and CARMA1. J. Exp. Med., 202, 1423-1431, 2005.

86.Kawano Y, Yoshikawa S, Minegishi Y, Karasuyama H. Selection of stereotyped VH81X-H chains via pre-B cell receptor early in ontogeny and their conservation in adults by marginal zone B cells. Int. Immunol. (7): 857-67, 2005

87.Shinohara, H., Inoue, A., Toyama-Sorimachi, N., Nagai, Y., Yasuda, T., Suzuki, H., Horai, R., Iwakura, Y., Yamamoto, T., Karasuyama, H., Miyake, K. and Yamanashi, Y. Dok-1 and Dok-2 are negative regulators of lipopolysaccharide-induced signaling. J. Exp. Med., 201, 333-339, 2005.

88.Katakura, Y., Yoshizaki, K., Yasuda, T., Tsunematsu, T., Uehara, N., Miura, T., Fujiki, T., and Shirahata, S. Functional impairment of telomerase in sublines derived from human lung adenocarcinoma exposed to mild oxidative stress. Biochem. Biophys. Res. Commun., 334, 450-459, 2005.

89.Yasuda, T., Shirakata, M., Iwama, A., Ishii, A., Ebihara, Y., Osawa, M., Honda, K., Shinohara, H., Sudo, K., Tsuji, K., Nakauchi, H., Iwakura, Y., Hirai, H., Oda, H., Yamamoto, T., and Yamanashi, Y. Role of Dok-1 and Dok-2 in myeloid homeostasis and suppression of leukemia. J. Exp. Med., 200, 1681-1687, 2004.

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92.Yasuda, T., Tezuka, T., Maeda, A., Inazu, T., Yamanashi, Y., Gu, H., Kurosaki, T., and Yamamoto T. Cbl-b positively regulates Btk-mediated activation of phospholipase C-γ2 in B Cells. J. Exp. Med., 196, 51-63, 2002.

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競争的研究費取得状況

保田朋波流
1.2021-2023年度 基盤研究(B)「免疫特性と癌化に及ぼすリンパ球増殖限界のエピジェネティックな制御基盤」
2. 2019-2020年度 挑戦的研究(萌芽)「体細胞寿命および新旧細胞間相互作用の解析」
3.2018-2020年度 基盤研究(B)「免疫特性と癌化に及ぼすリンパ球増殖限界制御の分子基盤」
4. 2017-2018年度 研究活動スタート支援「癌化と感染防御におけるB細胞増殖限界制御の分子基盤」
5. 2017年度 九州大学QRプログラム(わかばチャレンジ)「免疫細胞の増殖限界制御機構の解明」
6. 2017年度 公益信託 日本白血病研究基金「リンパ腫発症における細胞老化因子の解析」
7. 2017年度 公益財団法人 先進医薬研究振興財団(血液医学分野研究助成)「免疫細胞の増殖限界制御の分子基盤」
8. 2008-2009年度 若手研究(B)「T細胞依存性抗原に対するB細胞応答におけるErkの役割の解明」
9. 2006-2007年度 若手研究(B)「BCR下流のアダプター分子BLNKと会合する新規シグナル分子の機能解析」

河野洋平
1. 2020年度 武田薬品工業(COCKPI-T) 「cCLPを利用した効率的かつ大量の免疫寛容誘導性形質樹状細胞取得法の開発」
2. 2019年度 公益財団法人 先進医薬研究振興財団 血液医学分野研究助成「cCLPの増殖維持に関わる支持細胞由来因子の同定」
3. 2018-2020年度 武田科学振興財団 医学研究助成「新規生体機能遺伝子スクリーニング法を用いたアレルギー性炎症抑制機構の解明」
4. 2014-2015年度Humboldt Research Fellowship for Experienced Researchers 「Identification of exogenous factors to improve the generation of pluripotent hematopoietic stem cells from embryonic stem cells」
5. 2011-2013年度 文部科学省科学研究費補助金 若手研究(B)「プレBCRダウンレギュレーションにおけるリソソーム膜分子Laptm5の役割」
6. 2009-2011年度 文部科学省科学研究費補助金 若手研究(B)「プレB細胞レセプターの発現制御機構と急性リンパ性白血病化の解明」
7. 2006-2008年度 文部科学省科学研究費 若手研究(B)「プレB細胞レセプターの発現調節機構の解明」

郭芸
1. 2017-2018年度 若手研究(B)「The regulation of the ubiquitin-editing protein A20 in thymic selection」
2. 2013年度 広島大学女性研究者奨励賞 「NF-kB シグナルソームのユビキチン制御蛋白質A20 による、免疫反応・炎症の解析と免疫老化の関係」

下岡清美
1. 2018-2019年度 若手研究「腫瘍浸潤Tリンパ球のT細胞受容体のがん特異性の検証と新規がん抗原の同定」

北嶋康雄
1. 2020-2024年度 文部科学省 卓越研究員事業卓越研究員「骨格筋再生における包括的な制御機構の解明」
2. 2020-2023年度 基盤研究(B)「骨格筋再生における筋幹細胞の新たなダイナミクスの解明」
3. 2020-2021年度 公益財団法人 武田科学振興財団「加齢性筋肉減弱症の予防・改善のための骨格筋幹細胞の維持機構の解明」
4. 2020年度 公益財団法人 鈴木謙三記念医科学応用研究財団「加齢性筋肉減弱症の病態解明における骨格筋幹細胞の基礎的研究」
5. 2018-2019年度 若手研究「骨格筋幹細胞における老化制御機構の解明」
6. 2018年度 公益財団法人 上原記念生命科学財団「骨格筋幹細胞における老化機構の解明に関する研究」
7. 2017年度 公益財団法人 中冨健康科学振興財団「骨格筋再生過程におけるタンパク分解機構の役割解明に関する研究」
8. 2016年度 公益財団法人 明治安田厚生事業団「骨格筋量を決定するタンパク分解系に着目した筋再生メカニズムの解明に関する研究」
9. 2016-2018年度 日本学術振興会 特別研究員SPD奨励費「タンパク分解系に着目した筋幹細胞調節機構の解明」
10. 2015年度 公益財団法人 ヤマハ発動機研究助成「骨格筋萎縮時における筋代謝特性の解明-骨格筋代謝物質の網羅解析による検証-」
11. 2015-2018年度 若手研究(B)「骨格筋におけるプロテアソームの筋量調節機構の解明」
12. 2013年度 公益財団法人 日本科学協会「骨格筋量決定における蛋白分解処理機構の役割」

河原隆浩
1. 2020年度 公益財団法人 ニッポンハム食の未来財団(個人研究助成)「経皮感作食物アレルギーモデル確立と脂肪酸摂取によるアレルギー制御」