業績

1. W Winkler, C Farre Diaz, E Blanc, H Napieczynska, P Langner, M Werner, B Walter, B Wollert-Wulf, T Yasuda, A Heuser, D Beule, S Mathas, I Anagnostopoulos, A Rosenwald, K Rajewsky and M Janz. Mouse models of human multiple myeloma subgroups. Proc Natl Acad Sci U S A 120:e2219439120, 2023. DOI:10.1073/pnas.2219439120

2. Y Sugiyama, T Harada, Y Kamei, T Yasuda, T Mashimo, A Nishikimi and M Maruyama. A senolytic immunotoxin eliminates p16(INK4a)-positive T cells and ameliorates age-associated phenotypes of CD4(+) T cells in a surface marker knock-in mouse. Exp Gerontol 174:112130, 2023. DOI:10.1016/j.exger.2023.112130

3. M Morita, S Kitanobo, S Ohki, K Shiba and K Inaba. Positive selection on ADAM10 builds species recognition in the synchronous spawning coral Acropora. Front Cell Dev Biol 11:1171495, 2023. DOI:10.3389/fcell.2023.1171495

4. K Inoue, T Yasuda, Y Baba, T Yamamoto, T Kurosaki and H Shinohara. Regulation mechanisms of CARMA1-Bcl10-MALT1 complex assembly inferred from the analysis of TRAF6-deficient cells. Genes Cells, 2023. DOI:10.1111/gtc.13022

5. K Hirano, M Tsuchiya, A Shiomi, S Takabayashi, M Suzuki, Y Ishikawa, Y Kawano, Y Takabayashi, K Nishikawa, K Nagao, E Umemoto, Y Kitajima, Y Ono, K Nonomura, H Shintaku, Y Mori, M Umeda and Y Hara. The mechanosensitive ion channel PIEZO1 promotes satellite cell function in muscle regeneration. Life Sci Alliance 6:10.26508/lsa.202201783, 2023. DOI:10.26508/lsa.202201783

6. H Azuma, Y Kawano, K Shitaoka, T Kawahara, A Ito, A Higashiura, Y Kitajima, S Ohki and T Yasuda. Vaccination with the Omicron spike RBD boosts broadly neutralizing antibody levels and confers sustained protection even after acquiring immunity to the original antigen. Int Immunol 35:197-207, 2023. DOI:10.1093/intimm/dxac055

7. A Widyagarini, N Nishii, Y Kawano, C Zhang and M Azuma. VSIG4/CRIg directly regulates early CD8(+) T cell activation through its counter-receptor in a narrow window. Biochem Biophys Res Commun 614:100-106, 2022. DOI:10.1016/j.bbrc.2022.04.120

8. Y Tamura, K Yamane, Y Kawano, L Bullinger, T Wirtz, T Weber, S Sander, S Ohki, Y Kitajima, S Okada, K Rajewsky and T Yasuda. Concomitant Cytotoxic Effector Differentiation of CD4(+) and CD8(+) T Cells in Response to EBV-Infected B Cells. Cancers (Basel) 14:10.3390/cancers14174118, 2022. DOI:10.3390/cancers14174118

9. H Sushida, H Sakai, N Moriya, K Nakano, N Ashimine, M Minami, H Tamotsu, T Nakanishi, S Ohki, K Teruya, T Hirano, S Yamasaki, C Suzuki, K Satou and H Kimoto-Nira. Complete Genome Sequence of Lactococcus cremoris Strain 7-1, a Lactic Acid Bacterium Isolated from a Traditional Mongolian Milk Product Possessing Mucin-Adhesive Ability. Microbiol Resour Announc 11:e0014322, 2022. DOI:10.1128/mra.00143-22

10. H Shiraki, S Tanaka, Y Guo, K Harada, I Hide, T Yasuda and N Sakai. Potential role of inducible GPR3 expression under stimulated T cell conditions. J Pharmacol Sci 148:307-314, 2022. DOI:10.1016/j.jphs.2022.01.005

11. S Osana, Y Kitajima, S Naoki, H Takada, K Murayama, Y Kano and R Nagatomi. Little involvement of recycled-amino acids from proteasomal proteolysis in de novo protein synthesis. Biochem Biophys Res Commun 634:40-47, 2022. DOI:10.1016/j.bbrc.2022.09.113

12. S Mise, A Matsumoto, K Shimada, T Hosaka, M Takahashi, K Ichihara, H Shimizu, C Shiraishi, D Saito, M Suyama, T Yasuda, T Ide, Y Izumi, T Bamba, T Kimura-Someya, M Shirouzu, H Miyata, M Ikawa and KI Nakayama. Kastor and Polluks polypeptides encoded by a single gene locus cooperatively regulate VDAC and spermatogenesis. Nat Commun 13:1071, 2022. DOI:10.1038/s41467-022-28677-y

13. E Kobayashi, A Jin, H Hamana, K Shitaoka, K Tajiri, S Kusano, S Yokoyama, T Ozawa, T Obata, A Muraguchi and H Kishi. Rapid cloning of antigen-specific T-cell receptors by leveraging the cis activation of T cells. Nat Biomed Eng 6:806-818, 2022. DOI:10.1038/s41551-022-00874-6

14. Y Kitajima, R Tsukahara, S Nakamoto and T Yasuda. Efficient Isolation of Lymphocytes and Myogenic Cells from the Tissue of Muscle Regeneration. Cells 11:10.3390/cells11111754, 2022. DOI:10.3390/cells11111754

15. K Yoshioka, H Nagahisa, F Miura, H Araki, Y Kamei, Y Kitajima, D Seko, J Nogami, Y Tsuchiya, N Okazaki, A Yonekura, S Ohba, Y Sumita, K Chiba, K Ito, I Asahina, Y Ogawa, T Ito, Y Ohkawa and Y Ono. Hoxa10 mediates positional memory to govern stem cell function in adult skeletal muscle. Sci Adv 7:10.1126/sciadv.abd7924, 2021. DOI:10.1126/sciadv.abd7924

16. K Yoshioka, Y Kitajima, D Seko, Y Tsuchiya and Y Ono. The body region specificity in murine models of muscle regeneration and atrophy. Acta Physiol (Oxf) 231:e13553, 2021. DOI:10.1111/apha.13553

17. T Yasuda, Y Saito, C Ono, K Kawata, A Baba and Y Baba. Generation and characterization of CD19-iCre mice as a tool for efficient and specific conditional gene targeting in B cells. Sci Rep 11:5524, 2021. DOI:10.1038/s41598-021-84786-6

18. S Yamaguchi, H Hamana, K Shitaoka, K Sukegawa, T Nagata, A Hayee, E Kobayashi, T Ozawa, T Fujii, A Muraguchi, K Tobe and H Kishi. TCR function analysis using a novel system reveals the multiple unconventional tumor-reactive T cells in human breast cancer-infiltrating lymphocytes. Eur J Immunol 51:2306-2316, 2021. DOI:10.1002/eji.202049070

19. N Tsugawa, D Yamada, T Watabe, M Onizawa, S Wang, Y Nemoto, S Oshima, T Tsubata, T Adachi, Y Kawano, M Watanabe, RS Blumberg, R Okamoto and T Nagaishi. CEACAM1 specifically suppresses B cell receptor signaling-mediated activation. Biochem Biophys Res Commun 535:99-105, 2021. DOI:10.1016/j.bbrc.2020.11.126

20. J Tezuka, M Sanefuji, T Ninomiya, T Kawahara, H Matsuzaki, Y Sonoda, M Ogawa, M Shimono, R Suga, S Honjo, K Kusuhara, S Ohga and CsSG Japan Environment. Possible association between early formula and reduced risk of cow's milk allergy: The Japan Environment and Children's Study. Clin Exp Allergy 51:99-107, 2021. DOI:10.1111/cea.13761

21. T Sakurai, M Kukimoto-Niino, K Kunimura, N Yamane, D Sakata, R Aihara, T Yasuda, S Yokoyama, M Shirouzu, Y Fukui and T Uruno. A conserved PI(4,5)P2-binding domain is critical for immune regulatory function of DOCK8. Life Sci Alliance 4:10.26508/lsa.202000873, 2021. DOI:10.26508/lsa.202000873

22. S Osana, Y Kitajima, N Suzuki, A Nunomiya, H Takada, T Kubota, K Murayama and R Nagatomi. Puromycin-sensitive aminopeptidase is required for C2C12 myoblast proliferation and differentiation. J Cell Physiol 236:5293-5305, 2021. DOI:10.1002/jcp.30237

23. A Nita, A Matsumoto, R Tang, C Shiraishi, K Ichihara, D Saito, M Suyama, T Yasuda, G Tsuji, M Furue, B Katayama, T Ozawa, T Murata, T Dainichi, K Kabashima, A Hatano, M Matsumoto and KI Nakayama. A ubiquitin-like protein encoded by the "noncoding" RNA TINCR promotes keratinocyte proliferation and wound healing. PLoS Genet 17:e1009686, 2021. DOI:10.1371/journal.pgen.1009686

24. M Mojic, K Shitaoka, C Ohshima, S Ucche, F Lyu, H Hamana, H Tahara, H Kishi and Y Hayakawa. NKG2D defines tumor-reacting effector CD8(+) T cells within tumor microenvironment. Cancer Sci 112:3484-3490, 2021. DOI:10.1111/cas.15050

25. WS Kong, N Tsuyama, H Inoue, Y Guo, S Mokuda, A Nobukiyo, N Nakatani, F Yamaide, T Nakano, Y Kohno, K Ikeda, Y Nakanishi, H Ohno, M Arita, N Shimojo and M Kanno. Long-chain saturated fatty acids in breast milk are associated with the pathogenesis of atopic dermatitis via induction of inflammatory ILC3s. Sci Rep 11:13109, 2021. DOI:10.1038/s41598-021-92282-0

26. S Huang and T Yasuda. Pathologically Relevant Mouse Models for Epstein-Barr Virus-Associated B Cell Lymphoma. Front Immunol 12:639844, 2021. DOI:10.3389/fimmu.2021.639844

27. K Yoshioka, Y Kitajima, N Okazaki, K Chiba, A Yonekura and Y Ono. A Modified Pre-plating Method for High-Yield and High-Purity Muscle Stem Cell Isolation From Human/Mouse Skeletal Muscle Tissues. Front Cell Dev Biol 8:793, 2020. DOI:10.3389/fcell.2020.00793

28. Y Yang, S Nagai, S Kang, Y Xia, Y Kawano, K Miyake, H Karasuyama and M Azuma. Tolerogenic properties of CD206+ macrophages appeared in the sublingual mucosa after repeated antigen-painting. Int Immunol 32:509-518, 2020. DOI:10.1093/intimm/dxaa014

29. Y Tsuchiya, Y Kitajima, H Masumoto and Y Ono. Damaged Myofiber-Derived Metabolic Enzymes Act as Activators of Muscle Satellite Cells. Stem Cell Reports 15:926-940, 2020. DOI:10.1016/j.stemcr.2020.08.002

30. K Sukegawa, K Shitaoka, H Hamana, E Kobayashi, Y Miyahara, K Fujii, K Tsuda, S Saeki, T Nagata, T Ozawa, S Saito, T Fujii, A Muraguchi, H Shiku and H Kishi. Relationship between T cell receptor clonotype and PD-1 expression of tumor-infiltrating lymphocytes in colorectal cancer. Eur J Immunol 50:1580-1590, 2020. DOI:10.1002/eji.201948399

31. T Sommermann, T Yasuda, J Ronen, T Wirtz, T Weber, U Sack, R Caeser, J Zhang, X Li, VT Chu, A Jauch, K Unger, DJ Hodson, A Akalin and K Rajewsky. Functional interplay of Epstein-Barr virus oncoproteins in a mouse model of B cell lymphomagenesis. Proc Natl Acad Sci U S A 117:14421-14432, 2020. DOI:10.1073/pnas.1921139117

32. S Osana, Y Kitajima, N Suzuki, Y Xu, K Murayama and R Nagatomi. siRNA knockdown of alanine aminopeptidase impairs myoblast proliferation and differentiation. Exp Cell Res 397:112337, 2020. DOI:10.1016/j.yexcr.2020.112337

33. H Ono, N Suzuki, SI Kanno, G Kawahara, R Izumi, T Takahashi, Y Kitajima, S Osana, N Nakamura, T Akiyama, K Ikeda, T Shijo, S Mitsuzawa, R Nagatomi, N Araki, A Yasui, H Warita, YK Hayashi, K Miyake and M Aoki. AMPK Complex Activation Promotes Sarcolemmal Repair in Dysferlinopathy. Mol Ther 28:1133-1153, 2020. DOI:10.1016/j.ymthe.2020.02.006

34. Y Kitajima, K Yoshioka and N Suzuki. The ubiquitin-proteasome system in regulation of the skeletal muscle homeostasis and atrophy: from basic science to disorders. J Physiol Sci 70:40, 2020. DOI:10.1186/s12576-020-00768-9

35. Y Kitajima, N Suzuki, K Yoshioka, R Izumi, M Tateyama, Y Tashiro, R Takahashi, M Aoki and Y Ono. Inducible Rpt3, a Proteasome Component, Knockout in Adult Skeletal Muscle Results in Muscle Atrophy. Front Cell Dev Biol 8:859, 2020. DOI:10.3389/fcell.2020.00859

36. M Furukawa, S Ohki, S Kitanobo, H Fukami and M Morita. Differences in spawning time drive cryptic speciation in the coral Acropora divaricata. Marine Biology 167:10.1007/s00227-00020-03781-z, 2020. DOI:10.1007/s00227-020-03781-z

37. S Yoshikawa, M Oh-Hora, R Hashimoto, T Nagao, L Peters, M Egawa, T Ohta, K Miyake, T Adachi, Y Kawano, Y Yamanishi and H Karasuyama. Pivotal role of STIM2, but not STIM1, in IL-4 production by IL-3-stimulated murine basophils. Sci Signal 12:10.1126/scisignal.aav2060, 2019. DOI:10.1126/scisignal.aav2060

38. M Sato, S Hosoya, S Yoshikawa, S Ohki, Y Kobayashi, T Itou and K Kikuchi. A highly flexible and repeatable genotyping method for aquaculture studies based on target amplicon sequencing using next-generation sequencing technology. Sci Rep 9:6904, 2019. DOI:10.1038/s41598-019-43336-x

39. T Nagao, Y Yamanishi, K Miyake, M Teranishi, S Takahashi, S Yoshikawa, Y Kawano and H Karasuyama. Aggregation makes a protein allergenic at the challenge phase of basophil-mediated allergy in mice. Int Immunol 31:41-49, 2019. DOI:10.1093/intimm/dxy062

40. T Kawahara, J Tezuka, T Ninomiya, S Honjo, N Masumoto, M Nanishi, H Nakayama and S Ohga. Risk prediction of severe reaction to oral challenge test of cow's milk. Eur J Pediatr 178:181-188, 2019. DOI:10.1007/s00431-018-3274-z

41. K Imami and T Yasuda. Measuring Protein Synthesis during Cell Cycle by Azidohomoalanine (AHA) Labeling and Flow Cytometric Analysis. Bio Protoc 9:e3215, 2019. DOI:10.21769/BioProtoc.3215

42. K Hosokawa, E Kobayashi, Y Akatsuka, L Espinoza, N Nakagawa, T Mikoto, N Tsuji, T Yoroidaka, H Mizumaki, TMA Nguyen, T Katagiri, K Shitaoka, H Hamana, H Kishi and S Nakao. Identification of T-Cell Receptors Specific to Antigens Presented By HLA-B4002 and B5401 in Acquired Aplastic Anemia. Blood 134:10.1182/blood-2019-125685, 2019. DOI:10.1182/blood-2019-125685

43. T Akiyama, N Suzuki, M Ishikawa, K Fujimori, T Sone, J Kawada, R Funayama, F Fujishima, S Mitsuzawa, K Ikeda, H Ono, T Shijo, S Osana, M Shirota, T Nakagawa, Y Kitajima, A Nishiyama, R Izumi, S Morimoto, Y Okada, T Kamei, M Nishida, M Nogami, S Kaneda, Y Ikeuchi, H Mitsuhashi, K Nakayama, T Fujii, H Warita, H Okano and M Aoki. Aberrant axon branching via Fos-B dysregulation in FUS-ALS motor neurons. EBioMedicine 45:362-378, 2019. DOI:10.1016/j.ebiom.2019.06.013

44. K Tsuda, H Kishi, A Nakashima, H Hamana, A Ushijima, S Tsuda, T Shima, K Shitaoka, E Kobayashi, T Ozawa, O Yoshino and S Saito. TCR repertoire analysis of cytotoxic T cell in peripheral blood in uterine endometrial cancer. Journal of Reproductive Immunology 130:44-44, 2018. DOI:10.1016/j.jri.2018.09.041

45. Y Tabakawa, T Ohta, S Yoshikawa, EJ Robinson, K Yamaji, K Ishiwata, Y Kawano, K Miyake, Y Yamanishi, H Ohtsu, T Adachi, N Watanabe, H Kanuka and H Karasuyama. Histamine Released From Skin-Infiltrating Basophils but Not Mast Cells Is Crucial for Acquired Tick Resistance in Mice. Front Immunol 9:1540, 2018. DOI:10.3389/fimmu.2018.01540

46. K Shitaoka, H Hamana, H Kishi, Y Hayakawa, E Kobayashi, K Sukegawa, X Piao, F Lyu, T Nagata, D Sugiyama, H Nishikawa, A Tanemura, I Katayama, M Murahashi, Y Takamatsu, K Tani, T Ozawa and A Muraguchi. Identification of Tumoricidal TCRs from Tumor-Infiltrating Lymphocytes by Single-Cell Analysis. Cancer Immunol Res 6:378-388, 2018. DOI:10.1158/2326-6066.CIR-17-0489

47. T Shijo, H Warita, N Suzuki, Y Kitajima, K Ikeda, T Akiyama, H Ono, S Mitsuzawa, A Nishiyama, R Izumi and M Aoki. Aberrant astrocytic expression of chondroitin sulfate proteoglycan receptors in a rat model of amyotrophic lateral sclerosis. J Neurosci Res 96:222-233, 2018. DOI:10.1002/jnr.24127

48. T Shijo, H Warita, N Suzuki, K Ikeda, S Mitsuzawa, T Akiyama, H Ono, A Nishiyama, R Izumi, Y Kitajima and M Aoki. Antagonizing bone morphogenetic protein 4 attenuates disease progression in a rat model of amyotrophic lateral sclerosis. Exp Neurol 307:164-179, 2018. DOI:10.1016/j.expneurol.2018.06.009

49. G Petkau, Y Kawano, I Wolf, M Knoll and F Melchers. MiR221 promotes precursor B-cell retention in the bone marrow by amplifying the PI3K-signaling pathway in mice. Eur J Immunol 48:975-989, 2018. DOI:10.1002/eji.201747354

50. S Ohki, T Hagi, K Nakano, A Shiroma, H Tamotsu, M Shimoji, M Shinzato, N Ashimine, M Minami, T Nakanishi, K Teruya, K Satou, N Moriya, M Kobayashi, M Nomura, C Suzuki and T Hirano. Complete Genome Sequence of Carotenoid-Producing Enterococcus gilvus CR1, Isolated from Raw Cow's Milk. Microbiol Resour Announc 7:10.1128/MRA.00988-00918, 2018. DOI:10.1128/MRA.00988-18

51. K Nakano, M Minami, M Shinzato, M Shimoji, N Ashimine, A Shiroma, S Ohki, T Nakanishi, H Tamotsu, K Teruya, K Satou, N Moriya, H Kimoto-Nira, M Kobayashi, T Hagi, M Nomura, C Suzuki and T Hirano. Complete Genome Sequence of Lactococcus lactis subsp. lactis G50 with Immunostimulating Activity, Isolated from Napier Grass. Genome Announc 6:10.1128/genomeA.00069-00018, 2018. DOI:10.1128/genomeA.00069-18

52. N Moriya, K Nakano, A Shiroma, M Shinzato, N Ashimine, M Minami, H Tamotsu, M Shimoji, T Nakanishi, S Ohki, K Teruya, K Satou, T Hirano, T Hagi, M Kobayashi, M Nomura, H Kimoto-Nira, K Tajima, Y Cai and C Suzuki. Complete Genome Sequence of Lactobacillus plantarum Strain LQ80, Selected for Preparation of Fermented Liquid Feed for Pigs. Genome Announc 6:10.1128/genomeA.00530-00518, 2018. DOI:10.1128/genomeA.00530-18

53. Y Kitajima, N Suzuki, A Nunomiya, S Osana, K Yoshioka, Y Tashiro, R Takahashi, Y Ono, M Aoki and R Nagatomi. The Ubiquitin-Proteasome System Is Indispensable for the Maintenance of Muscle Stem Cells. Stem Cell Reports 11:1523-1538, 2018. DOI:10.1016/j.stemcr.2018.10.009

54. Y Kitajima and Y Ono. Visualization of PAX7 protein dynamics in muscle satellite cells in a YFP knock-in-mouse line. Skelet Muscle 8:26, 2018. DOI:10.1186/s13395-018-0174-x

55. Y Kawano, G Petkau, C Stehle, P Durek, GA Heinz, K Tanimoto, H Karasuyama, MF Mashreghi, C Romagnani and F Melchers. Stable lines and clones of long-term proliferating normal, genetically unmodified murine common lymphoid progenitors. Blood 131:2026-2035, 2018. DOI:10.1182/blood-2017-09-805259

56. T Kawahara, Masumoto, N., and Tezuka, J. Risk factors for severe reactions in a low-dose oral food challenge in cow's milk. Nihon Shoni Arerugi Gakkaishi. 32:647-653, 2018. DOI:doi.org/10.3388/jspaci.32.647

57. H Karasuyama, K Miyake, S Yoshikawa, Y Kawano and Y Yamanishi. How do basophils contribute to Th2 cell differentiation and allergic responses? Int Immunol 30:391-396, 2018. DOI:10.1093/intimm/dxy026

58. K Imami, M Milek, B Bogdanow, T Yasuda, N Kastelic, H Zauber, Y Ishihama, M Landthaler and M Selbach. Phosphorylation of the Ribosomal Protein RPL12/uL11 Affects Translation during Mitosis. Mol Cell 72:84-98 e89, 2018. DOI:10.1016/j.molcel.2018.08.019

59. K Ikegami, Y Aita, A Shiroma, M Shimoji, H Tamotsu, N Ashimine, M Shinzato, S Ohki, K Nakano, K Teruya, K Satou, T Hirano and M Yohda. Complete Genome Sequence of Petrimonas sp. Strain IBARAKI, Assembled from the Metagenome Data of a Culture Containing Dehalococcoides spp. Genome Announc 6:10.1128/genomeA.00384-00318, 2018. DOI:10.1128/genomeA.00384-18

60. VM Ho, N Hirohashi, WS Kong, G Yun, K Ota, J Itai, S Yamaga, K Suzuki, K Tanigawa, M Kanno and N Shime. Sera from Septic Patients Contain the Inhibiting Activity of the Extracellular ATP-Dependent Inflammasome Pathway. Tohoku J Exp Med 245:193-204, 2018. DOI:10.1620/tjem.245.193

61. A Harada, K Maehara, Y Ono, H Taguchi, K Yoshioka, Y Kitajima, Y Xie, Y Sato, T Iwasaki, J Nogami, S Okada, T Komatsu, Y Semba, T Takemoto, H Kimura, H Kurumizaka and Y Ohkawa. Histone H3.3 sub-variant H3mm7 is required for normal skeletal muscle regeneration. Nat Commun 9:1400, 2018. DOI:10.1038/s41467-018-03845-1

62. S Fujimaki, D Seko, Y Kitajima, K Yoshioka, Y Tsuchiya, S Masuda and Y Ono. Notch1 and Notch2 Coordinately Regulate Stem Cell Function in the Quiescent and Activated States of Muscle Satellite Cells. Stem Cells 36:278-285, 2018. DOI:10.1002/stem.2743

63. Y Asahina, A Shiroma, K Nakano, H Tamotsu, N Ashimine, M Shinzato, M Minami, M Shimoji, T Nakanishi, S Ohki, K Teruya, K Satou, M Kobayashi, T Hagi, N Moriya, C Suzuki, A Tajima, M Nomura and T Hirano. Complete Genome Sequence of Lactobacillus paracasei EG9, a Strain Accelerating Free Amino Acid Production during Cheese Ripening. Genome Announc 6:10.1128/genomeA.00627-00618, 2018. DOI:10.1128/genomeA.00627-18

64. M Yohda, K Ikegami, Y Aita, M Kitajima, A Takechi, M Iwamoto, T Fukuda, N Tamura, J Shibasaki, S Koike, D Komatsu, S Miyagi, M Nishimura, Y Uchino, A Shiroma, M Shimoji, H Tamotsu, N Ashimine, M Shinzato, S Ohki, K Nakano, K Teruya, K Satou, T Hirano and O Yagi. Isolation and genomic characterization of a Dehalococcoides strain suggests genomic rearrangement during culture. Sci Rep 7:2230, 2017. DOI:10.1038/s41598-017-02381-0

65. J Tornack, Y Kawano, N Garbi, GJ Hammerling, F Melchers and M Tsuneto. Flt3 ligand-eGFP-reporter expression characterizes functionally distinct subpopulations of CD150(+) long-term repopulating murine hematopoietic stem cells. Eur J Immunol 47:1477-1487, 2017. DOI:10.1002/eji.201646730

66. T Ohta, S Yoshikawa, Y Tabakawa, K Yamaji, K Ishiwata, H Shitara, C Taya, M Oh-Hora, Y Kawano, K Miyake, Y Yamanishi, H Yonekawa, N Watanabe, H Kanuka and H Karasuyama. Skin CD4(+) Memory T Cells Play an Essential Role in Acquired Anti-Tick Immunity through Interleukin-3-Mediated Basophil Recruitment to Tick-Feeding Sites. Front Immunol 8:1348, 2017. DOI:10.3389/fimmu.2017.01348

67. A Nunomiya, J Shin, Y Kitajima, T Dan, T Miyata and R Nagatomi. Activation of the hypoxia-inducible factor pathway induced by prolyl hydroxylase domain 2 deficiency enhances the effect of running training in mice. Acta Physiol (Oxf) 220:99-112, 2017. DOI:10.1111/apha.12751

68. K Nakano, A Shiroma, M Shimoji, H Tamotsu, N Ashimine, S Ohki, M Shinzato, M Minami, T Nakanishi, K Teruya, K Satou and T Hirano. Advantages of genome sequencing by long-read sequencer using SMRT technology in medical area. Hum Cell 30:149-161, 2017. DOI:10.1007/s13577-017-0168-8

69. Y Kawano, G Petkau, I Wolf, J Tornack and F Melchers. IL-7 and immobilized Kit-ligand stimulate serum- and stromal cell-free cultures of precursor B-cell lines and clones. Eur J Immunol 47:206-212, 2017. DOI:10.1002/eji.201646677

70. T Wirtz, T Weber, S Kracker, T Sommermann, K Rajewsky and T Yasuda. Mouse model for acute Epstein-Barr virus infection. Proc Natl Acad Sci U S A 113:13821-13826, 2016. DOI:10.1073/pnas.1616574113

71. A Uruno, Y Yagishita, F Katsuoka, Y Kitajima, A Nunomiya, R Nagatomi, J Pi, SS Biswal and M Yamamoto. Nrf2-Mediated Regulation of Skeletal Muscle Glycogen Metabolism. Mol Cell Biol 36:1655-1672, 2016. DOI:10.1128/MCB.01095-15

72. H Shinohara, T Yasuda and T Kurosaki. TAK1 adaptor proteins, TAB2 and TAB3, link the signalosome to B-cell receptor-induced IKK activation. FEBS Lett 590:3264-3269, 2016. DOI:10.1002/1873-3468.12342

73. J Shin, A Nunomiya, Y Kitajima, T Dan, T Miyata and R Nagatomi. Prolyl hydroxylase domain 2 deficiency promotes skeletal muscle fiber-type transition via a calcineurin/NFATc1-dependent pathway. Skelet Muscle 6:5, 2016. DOI:10.1186/s13395-016-0079-5

74. X Piao, T Ozawa, H Hamana, K Shitaoka, A Jin, H Kishi and A Muraguchi. TRAIL-receptor 1 IgM antibodies strongly induce apoptosis in human cancer cells in vitro and in vivo. Oncoimmunology 5:e1131380, 2016. DOI:10.1080/2162402X.2015.1131380

75. K Nakano, A Shiroma, H Tamotsu, S Ohki, M Shimoji, N Ashimine, M Shinzato, M Minami, T Nakanishi, K Teruya, K Satou, C Suzuki, H Kimoto-Nira, M Kobayashi, K Mizumachi, R Aoki, S Miyata, K Yamamoto, Y Ohtake, T Eguchi-Ogawa, N Moriya, T Hagi, M Nomura and T Hirano. First Complete Genome Sequence of the Skin-Improving Lactobacillus curvatus Strain FBA2, Isolated from Fermented Vegetables, Determined by PacBio Single-Molecule Real-Time Technology. Genome Announc 4:10.1128/genomeA.00884-00816, 2016. DOI:10.1128/genomeA.00884-16

76. DJ Klionsky, ... Y Kitajima, ... and SM Zughaier. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy 12:1-222, 2016. DOI:10.1080/15548627.2015.1100356

77. Y Kitajima, S Ogawa and Y Ono. Visualizing the Functional Heterogeneity of Muscle Stem Cells. Methods Mol Biol 1516:183-193, 2016. DOI:10.1007/7651_2016_349

78. E Ishikawa, H Kosako, T Yasuda, M Ohmuraya, K Araki, T Kurosaki, T Saito and S Yamasaki. Protein kinase D regulates positive selection of CD4(+) thymocytes through phosphorylation of SHP-1. Nat Commun 7:12756, 2016. DOI:10.1038/ncomms12756

79. H Hamana, K Shitaoka, H Kishi, T Ozawa and A Muraguchi. A novel, rapid and efficient method of cloning functional antigen-specific T-cell receptors from single human and mouse T-cells. Biochem Biophys Res Commun 474:709-714, 2016. DOI:10.1016/j.bbrc.2016.05.015

80. E Derudder, S Herzog, V Labi, T Yasuda, K Kochert, M Janz, A Villunger, M Schmidt-Supprian and K Rajewsky. Canonical NF-kappaB signaling is uniquely required for the long-term persistence of functional mature B cells. Proc Natl Acad Sci U S A 113:5065-5070, 2016. DOI:10.1073/pnas.1604529113

81. S Cho, CJ Wu, T Yasuda, LO Cruz, AA Khan, LL Lin, DT Nguyen, M Miller, HM Lee, ML Kuo, DH Broide, K Rajewsky, AY Rudensky and LF Lu. miR-23 approximately 27 approximately 24 clusters control effector T cell differentiation and function. J Exp Med 213:235-249, 2016. DOI:10.1084/jem.20150990

82. T Yasuda. 2015. MAP kinase cascades in antigen receptor signaling and physiology. Current Topics in Microbiology and Immunology 393, 2015. DOI:10.1007/82_2015_481

83. M Yamaya, Y Shimotai, Y Hatachi, N Lusamba Kalonji, Y Tando, Y Kitajima, K Matsuo, H Kubo, R Nagatomi, S Hongo, M Homma and H Nishimura. The serine protease inhibitor camostat inhibits influenza virus replication and cytokine production in primary cultures of human tracheal epithelial cells. Pulm Pharmacol Ther 33:66-74, 2015. DOI:10.1016/j.pupt.2015.07.001

84. A Shiroma, Y Terabayashi, K Nakano, M Shimoji, H Tamotsu, N Ashimine, S Ohki, M Shinzato, K Teruya, K Satou and T Hirano. First Complete Genome Sequences of Staphylococcus aureus subsp. aureus Rosenbach 1884 (DSM 20231T), Determined by PacBio Single-Molecule Real-Time Technology. Genome Announc 3:10.1128/genomeA.00800-00815, 2015. DOI:10.1128/genomeA.00800-15

85. K Satou, M Shimoji, H Tamotsu, A Juan, N Ashimine, M Shinzato, C Toma, T Nohara, A Shiroma, K Nakano, K Teruya, Y Terabayashi, S Ohki, N Koizumi, S Okano, T Suzuki and T Hirano. Complete Genome Sequences of Low-Passage Virulent and High-Passage Avirulent Variants of Pathogenic Leptospira interrogans Serovar Manilae Strain UP-MMC-NIID, Originally Isolated from a Patient with Severe Leptospirosis, Determined Using PacBio Single-Molecule Real-Time Technology. Genome Announc 3:10.1128/genomeA.00882-00815, 2015. DOI:10.1128/genomeA.00882-15

86. S Sander, VT Chu, T Yasuda, A Franklin, R Graf, DP Calado, S Li, K Imami, M Selbach, M Di Virgilio, L Bullinger and K Rajewsky. PI3 Kinase and FOXO1 Transcription Factor Activity Differentially Control B Cells in the Germinal Center Light and Dark Zones. Immunity 43:1075-1086, 2015. DOI:10.1016/j.immuni.2015.10.021

87. S Ohki, RK Kowalski, S Kitanobo and M Morita. Changes in spawning time led to the speciation of the broadcast spawning corals Acropora digitifera and the cryptic species Acropora sp 1 with similar gamete recognition systems. Coral Reefs 34:1189-1198, 2015. DOI:10.1007/s00338-015-1337-4

88. K Nakano, Y Terabayashi, A Shiroma, M Shimoji, H Tamotsu, N Ashimine, S Ohki, M Shinzato, K Teruya, K Satou and T Hirano. First Complete Genome Sequence of Pseudomonas aeruginosa (Schroeter 1872) Migula 1900 (DSM 50071T), Determined Using PacBio Single-Molecule Real-Time Technology. Genome Announc 3:10.1128/genomeA.00932-00915, 2015. DOI:10.1128/genomeA.00932-15

89. K Nakano, Y Terabayashi, A Shiroma, M Shimoji, H Tamotsu, N Ashimine, S Ohki, M Shinzato, K Teruya, K Satou and T Hirano. First Complete Genome Sequence of Clostridium sporogenes DSM 795T, a Nontoxigenic Surrogate for Clostridium botulinum, Determined Using PacBio Single-Molecule Real-Time Technology. Genome Announc 3:10.1128/genomeA.00832-00815, 2015. DOI:10.1128/genomeA.00832-15

90. Y Murakawa, M Hinz, J Mothes, A Schuetz, M Uhl, E Wyler, T Yasuda, G Mastrobuoni, CC Friedel, L Dolken, S Kempa, M Schmidt-Supprian, N Bluthgen, R Backofen, U Heinemann, J Wolf, C Scheidereit and M Landthaler. RC3H1 post-transcriptionally regulates A20 mRNA and modulates the activity of the IKK/NF-kappaB pathway. Nat Commun 6:7367, 2015. DOI:10.1038/ncomms8367

91. Z Mou, J Li, T Boussoffara, H Kishi, H Hamana, P Ezzati, C Hu, W Yi, D Liu, F Khadem, I Okwor, P Jia, K Shitaoka, S Wang, M Ndao, C Petersen, J Chen, S Rafati, H Louzir, A Muraguchi, JA Wilkins and JE Uzonna. Identification of broadly conserved cross-species protective Leishmania antigen and its responding CD4+ T cells. Sci Transl Med 7:310ra167, 2015. DOI:10.1126/scitranslmed.aac5477

92. S Mokuda, T Miyazaki, Y Ito, S Yamasaki, H Inoue, Y Guo, WS Kong, M Kanno, K Takasugi, E Sugiyama and J Masumoto. The proto-oncogene survivin splice variant 2B is induced by PDGF and leads to cell proliferation in rheumatoid arthritis fibroblast-like synoviocytes. Sci Rep 5:9795, 2015. DOI:10.1038/srep09795

93. L LiHua, S Yoshikawa, T Ohta, K Horiguchi, Y Kawano, H Ohtsu, Y Yamanishi and H Karasuyama. Large particulate allergens can elicit mast cell-mediated anaphylaxis without exit from blood vessels as efficiently as do small soluble allergens. Biochem Biophys Res Commun 467:70-75, 2015. DOI:10.1016/j.bbrc.2015.09.120

94. H Kishi, H Hamana, K Shitaoka and A Muraguchi. Identification of tumor-specific T cell receptors from primary tumor-infiltrating lymphocytes. Journal for ImmunoTherapy of Cancer 3:1, 2015. DOI:10.1186/2051-1426-3-s2-p74

95. S Yasukawa, Y Miyazaki, C Yoshii, M Nakaya, N Ozaki, S Toda, E Kuroda, K Ishibashi, T Yasuda, Y Natsuaki, F Mi-ichi, E Iizasa, T Nakahara, M Yamazaki, K Kabashima, Y Iwakura, T Takai, T Saito, T Kurosaki, B Malissen, N Ohno, M Furue, H Yoshida and H Hara. An ITAM-Syk-CARD9 signalling axis triggers contact hypersensitivity by stimulating IL-1 production in dendritic cells. Nat Commun 5:3755, 2014. DOI:10.1038/ncomms4755

96. H Shinohara, M Behar, K Inoue, M Hiroshima, T Yasuda, T Nagashima, S Kimura, H Sanjo, S Maeda, N Yumoto, S Ki, S Akira, Y Sako, A Hoffmann, T Kurosaki and M Okada-Hatakeyama. Positive feedback within a kinase signaling complex functions as a switch mechanism for NF-kappaB activation. Science 344:760-764, 2014. DOI:10.1126/science.1250020

97. S Ohki, M Morita, S Kitanobo, AA Kowalska and RK Kowalski. Cryopreservation of Acropora digitifera sperm with use of sucrose and methanol based solution. Cryobiology 69:134-139, 2014. DOI:10.1016/j.cryobiol.2014.06.005

98. Y Kitajima, Y Tashiro, N Suzuki, H Warita, M Kato, M Tateyama, R Ando, R Izumi, M Yamazaki, M Abe, K Sakimura, H Ito, M Urushitani, R Nagatomi, R Takahashi and M Aoki. Proteasome dysfunction induces muscle growth defects and protein aggregation. J Cell Sci 127:5204-5217, 2014. DOI:10.1242/jcs.150961

99. T Yasuda, T Wirtz, B Zhang, T Wunderlich, M Schmidt-Supprian, T Sommermann and K Rajewsky. Studying Epstein-Barr virus pathologies and immune surveillance by reconstructing EBV infection in mice. Cold Spring Harb Symp Quant Biol 78:259-263, 2013. DOI:10.1101/sqb.2013.78.020222

100. S Ohki, T Irie, M Inoue, K Shinmen, H Kawahata, T Nakamura, A Kato, Y Nojiri, A Suzuki, K Sakai and R van Woesik. Calcification responses of symbiotic and aposymbiotic corals to near-future levels of ocean acidification. Biogeosciences 10:6807-6814, 2013. DOI:10.5194/bg-10-6807-2013

101. K Obata-Ninomiya, K Ishiwata, H Tsutsui, Y Nei, S Yoshikawa, Y Kawano, Y Minegishi, N Ohta, N Watanabe, H Kanuka and H Karasuyama. The skin is an important bulwark of acquired immunity against intestinal helminths. J Exp Med 210:2583-2595, 2013. DOI:10.1084/jem.20130761

102. A Farmawati, Y Kitajima, T Nedachi, M Sato, M Kanzaki and R Nagatomi. Characterization of contraction-induced IL-6 up-regulation using contractile C2C12 myotubes. Endocr J 60:137-147, 2013. DOI:10.1507/endocrj.ej12-0316

103. M Egawa, K Mukai, S Yoshikawa, M Iki, N Mukaida, Y Kawano, Y Minegishi and H Karasuyama. Inflammatory monocytes recruited to allergic skin acquire an anti-inflammatory M2 phenotype via basophil-derived interleukin-4. Immunity 38:570-580, 2013. DOI:10.1016/j.immuni.2012.11.014

104. B Zhang, S Kracker, T Yasuda, S Casola, M Vanneman, C Homig-Holzel, Z Wang, E Derudder, S Li, T Chakraborty, SE Cotter, S Koyama, T Currie, GJ Freeman, JL Kutok, SJ Rodig, G Dranoff and K Rajewsky. Immune surveillance and therapy of lymphomas driven by Epstein-Barr virus protein LMP1 in a mouse model. Cell 148:739-751, 2012. DOI:10.1016/j.cell.2011.12.031

105. H Ogawa, K Mukai, Y Kawano, Y Minegishi and H Karasuyama. Th2-inducing cytokines IL-4 and IL-33 synergistically elicit the expression of transmembrane TNF-alpha on macrophages through the autocrine action of IL-6. Biochem Biophys Res Commun 420:114-118, 2012. DOI:10.1016/j.bbrc.2012.02.124

106. Y Kawano, R Ouchida, JY Wang, S Yoshikawa, M Yamamoto, D Kitamura and H Karasuyama. A novel mechanism for the autonomous termination of pre-B cell receptor expression via induction of lysosome-associated protein transmembrane 5. Mol Cell Biol 32:4462-4471, 2012. DOI:10.1128/MCB.00531-12

107. T Yasuda, K Kometani, N Takahashi, Y Imai, Y Aiba and T Kurosaki. ERKs induce expression of the transcriptional repressor Blimp-1 and subsequent plasma cell differentiation. Sci Signal 4:ra25, 2011. DOI:10.1126/scisignal.2001592

108. H Yamagishi, Y Mochizuki, T Hamakubo, K Obata, T Ugajin, S Sato, Y Kawano, Y Minegishi and H Karasuyama. Basophil-derived mouse mast cell protease 11 induces microvascular leakage and tissue edema in a mast cell-independent manner. Biochem Biophys Res Commun 415:709-713, 2011. DOI:10.1016/j.bbrc.2011.10.150

109. H Nishikado, K Mukai, Y Kawano, Y Minegishi and H Karasuyama. NK cell-depleting anti-asialo GM1 antibody exhibits a lethal off-target effect on basophils in vivo. J Immunol 186:5766-5771, 2011. DOI:10.4049/jimmunol.1100370

110. M Nakamura, S Ohki, A Suzuki and K Sakai. Coral larvae under ocean acidification: survival, metabolism, and metamorphosis. PLoS One 6:e14521, 2011. DOI:10.1371/journal.pone.0014521

111. Y Guo, M Miyazaki, M Itoi, R Satoh, A Iwama, T Amagai, H Kawamoto and M Kanno. Polycomb group gene Bmi1 plays a role in the growth of thymic epithelial cells. Eur J Immunol 41:1098-1107, 2011. DOI:10.1002/eji.201040794

112. T Wada, K Ishiwata, H Koseki, T Ishikura, T Ugajin, N Ohnuma, K Obata, R Ishikawa, S Yoshikawa, K Mukai, Y Kawano, Y Minegishi, H Yokozeki, N Watanabe and H Karasuyama. Selective ablation of basophils in mice reveals their nonredundant role in acquired immunity against ticks. J Clin Invest 120:2867-2875, 2010. DOI:10.1172/JCI42680

113. K Miyazaki, M Miyazaki, Y Guo, N Yamasaki, M Kanno, Z Honda, H Oda, H Kawamoto and H Honda. The role of the basic helix-loop-helix transcription factor Dec1 in the regulatory T cells. J Immunol 185:7330-7339, 2010. DOI:10.4049/jimmunol.1001381

114. S Kuchen, W Resch, A Yamane, N Kuo, Z Li, T Chakraborty, L Wei, A Laurence, T Yasuda, S Peng, J Hu-Li, K Lu, W Dubois, Y Kitamura, N Charles, HW Sun, S Muljo, PL Schwartzberg, WE Paul, J O'Shea, K Rajewsky and R Casellas. Regulation of microRNA expression and abundance during lymphopoiesis. Immunity 32:828-839, 2010. DOI:10.1016/j.immuni.2010.05.009

115. R Ishikawa, Y Tsujimura, K Obata, Y Kawano, Y Minegishi and H Karasuyama. IgG-mediated systemic anaphylaxis to protein antigen can be induced even under conditions of limited amounts of antibody and antigen. Biochem Biophys Res Commun 402:742-746, 2010. DOI:10.1016/j.bbrc.2010.10.098

116. S Yoshikawa, Y Kawano, Y Minegishi and H Karasuyama. The skewed heavy-chain repertoire in peritoneal B-1 cells is predetermined by the selection via pre-B cell receptor during B cell ontogeny in the fetal liver. Int Immunol 21:43-52, 2009. DOI:10.1093/intimm/dxn122

117. T Ugajin, T Kojima, K Mukai, K Obata, Y Kawano, Y Minegishi, Y Eishi, H Yokozeki and H Karasuyama. Basophils preferentially express mouse Mast Cell Protease 11 among the mast cell tryptase family in contrast to mast cells. J Leukoc Biol 86:1417-1425, 2009. DOI:10.1189/jlb.0609400

118. T Yasuda, H Sanjo, G Pages, Y Kawano, H Karasuyama, J Pouyssegur, M Ogata and T Kurosaki. Erk kinases link pre-B cell receptor signaling to transcriptional events required for early B cell expansion. Immunity 28:499-508, 2008. DOI:10.1016/j.immuni.2008.02.015

119. T Yasuda and T Kurosaki. Regulation of lymphocyte fate by Ras/ERK signals. Cell Cycle 7:3634-3640, 2008. DOI:10.4161/cc.7.23.7103

120. Y Tsujimura, K Obata, K Mukai, H Shindou, M Yoshida, H Nishikado, Y Kawano, Y Minegishi, T Shimizu and H Karasuyama. Basophils play a pivotal role in immunoglobulin-G-mediated but not immunoglobulin-E-mediated systemic anaphylaxis. Immunity 28:581-589, 2008. DOI:10.1016/j.immuni.2008.02.008

121. M Miyazaki, K Miyazaki, M Itoi, Y Katoh, Y Guo, R Kanno, Y Katoh-Fukui, H Honda, T Amagai, M van Lohuizen, H Kawamoto and M Kanno. Thymocyte proliferation induced by pre-T cell receptor signaling is maintained through polycomb gene product Bmi-1-mediated Cdkn2a repression. Immunity 28:231-245, 2008. DOI:10.1016/j.immuni.2007.12.013

122. T Hosooka, T Noguchi, K Kotani, T Nakamura, H Sakaue, H Inoue, W Ogawa, K Tobimatsu, K Takazawa, M Sakai, Y Matsuki, R Hiramatsu, T Yasuda, MA Lazar, Y Yamanashi and M Kasuga. Dok1 mediates high-fat diet-induced adipocyte hypertrophy and obesity through modulation of PPAR-gamma phosphorylation. Nat Med 14:188-193, 2008. DOI:10.1038/nm1706

123. T Yasuda, K Bundo, A Hino, K Honda, A Inoue, M Shirakata, M Osawa, T Tamura, H Nariuchi, H Oda, T Yamamoto and Y Yamanashi. Dok-1 and Dok-2 are negative regulators of T cell receptor signaling. Int Immunol 19:487-495, 2007. DOI:10.1093/intimm/dxm015

124. K Obata, K Mukai, Y Tsujimura, K Ishiwata, Y Kawano, Y Minegishi, N Watanabe and H Karasuyama. Basophils are essential initiators of a novel type of chronic allergic inflammation. Blood 110:913-920, 2007. DOI:10.1182/blood-2007-01-068718

125. Y Matsubara, I Kawasaki, S Urushiyama, T Yasuda, M Shirakata, Y Iino, H Shibuya and Y Yamanashi. The adaptor-like protein ROG-1 is required for activation of the Ras-MAP kinase pathway and meiotic cell cycle progression in Caenorhabditis elegans. Genes Cells 12:407-420, 2007. DOI:10.1111/j.1365-2443.2007.01061.x

126. A Inoue, T Yasuda, T Yamamoto and Y Yamanashi. Dok-1 is a positive regulator of IL-4 signalling and IgE response. J Biochem 142:257-263, 2007. DOI:10.1093/jb/mvm127

127. M Yamamoto, K Hayashi, T Nojima, Y Matsuzaki, Y Kawano, H Karasuyama, R Goitsuka and D Kitamura. BASH-novel PKC-Raf-1 pathway of pre-BCR signaling induces kappa gene rearrangement. Blood 108:2703-2711, 2006. DOI:10.1182/blood-2006-05-024968

128. Y Kawano, S Yoshikawa, Y Minegishi and H Karasuyama. Pre-B cell receptor assesses the quality of IgH chains and tunes the pre-B cell repertoire by delivering differential signals. J Immunol 177:2242-2249, 2006. DOI:10.4049/jimmunol.177.4.2242

129. M Honma, O Higuchi, M Shirakata, T Yasuda, H Shibuya, S Iemura, T Natsume and Y Yamanashi. Dok-3 sequesters Grb2 and inhibits the Ras-Erk pathway downstream of protein-tyrosine kinases. Genes Cells 11:143-151, 2006. DOI:10.1111/j.1365-2443.2006.00926.x

130. H Shinohara, T Yasuda, Y Aiba, H Sanjo, M Hamadate, H Watarai, H Sakurai and T Kurosaki. PKC beta regulates BCR-mediated IKK activation by facilitating the interaction between TAK1 and CARMA1. J Exp Med 202:1423-1431, 2005. DOI:10.1084/jem.20051591

131. H Shinohara, A Inoue, N Toyama-Sorimachi, Y Nagai, T Yasuda, H Suzuki, R Horai, Y Iwakura, T Yamamoto, H Karasuyama, K Miyake and Y Yamanashi. Dok-1 and Dok-2 are negative regulators of lipopolysaccharide-induced signaling. J Exp Med 201:333-339, 2005. DOI:10.1084/jem.20041817

132. Y Kawano, S Yoshikawa, Y Minegishi and H Karasuyama. Selection of stereotyped VH81X-microH chains via pre-B cell receptor early in ontogeny and their conservation in adults by marginal zone B cells. Int Immunol 17:857-867, 2005. DOI:10.1093/intimm/dxh265

133. Y Katakura, K Yoshizaki, T Yasuda, T Tsunematsu, N Uehara, T Miura, T Fujiki and S Shirahata. Functional impairment of telomerase in sublines derived from human lung adenocarcinoma exposed to mild oxidative stress. Biochem Biophys Res Commun 334:450-459, 2005. DOI:10.1016/j.bbrc.2005.06.109

134. T Yasuda and T Yamamoto. Analysis of B-cell signaling using DT40 B-cell line. Methods Mol Biol 271:261-270, 2004. DOI:10.1385/1-59259-796-3:261

135. T Yasuda, M Shirakata, A Iwama, A Ishii, Y Ebihara, M Osawa, K Honda, H Shinohara, K Sudo, K Tsuji, H Nakauchi, Y Iwakura, H Hirai, H Oda, T Yamamoto and Y Yamanashi. Role of Dok-1 and Dok-2 in myeloid homeostasis and suppression of leukemia. J Exp Med 200:1681-1687, 2004. DOI:10.1084/jem.20041247

136. H Shinohara, T Yasuda and Y Yamanashi. Dok-1 tyrosine residues at 336 and 340 are essential for the negative regulation of Ras-Erk signalling, but dispensable for rasGAP-binding. Genes Cells 9:601-607, 2004. DOI:10.1111/j.1356-9597.2004.00748.x

137. K Tsuchiya, Y Kawano, T Kojima, K Nagata, T Takao, M Okada, H Shinohara, K Maki, N Toyama-Sorimachi, N Miyasaka, M Watanabe and H Karasuyama. Molecular cloning and characterization of TPP36 and its isoform TPP32, novel substrates of Abl tyrosine kinase. FEBS Lett 537:203-209, 2003. DOI:10.1016/s0014-5793(03)00127-3

138. K Yokoyama, IH Su Ih, T Tezuka, T Yasuda, K Mikoshiba, A Tarakhovsky and T Yamamoto. BANK regulates BCR-induced calcium mobilization by promoting tyrosine phosphorylation of IP(3) receptor. EMBO J 21:83-92, 2002. DOI:10.1093/emboj/21.1.83

139. T Yasuda, T Tezuka, A Maeda, T Inazu, Y Yamanashi, H Gu, T Kurosaki and T Yamamoto. Cbl-b positively regulates Btk-mediated activation of phospholipase C-gamma2 in B cells. J Exp Med 196:51-63, 2002. DOI:10.1084/jem.20020068

140. M Magari, T Sawatari, Y Kawano, M Cascalho, M Wabl, N Kanayama, M Hikida and H Ohmori. Contribution of light chain rearrangement in peripheral B cells to the generation of high-affinity antibodies. Eur J Immunol 32:957-966, 2002. DOI:10.1002/1521-4141(200204)32:4<957::AID-IMMU957>3.0.CO;2-A

141. T Yasuda, A Maeda, M Kurosaki, T Tezuka, K Hironaka, T Yamamoto and T Kurosaki. Cbl suppresses B cell receptor-mediated phospholipase C (PLC)-gamma2 activation by regulating B cell linker protein-PLC-gamma2 binding. J Exp Med 191:641-650, 2000. DOI:10.1084/jem.191.4.641

142. Y Katakura, K Yamamoto, O Miyake, T Yasuda, N Uehara, E Nakata, S Kawamoto and S Shirahata. Bidirectional regulation of telomerase activity in a subline derived from human lung adenocarcinoma. Biochem Biophys Res Commun 237:313-317, 1997. DOI:10.1006/bbrc.1997.7104