業績

2022

1. A Widyagarini, N Nishii, Y Kawano, C Zhang and M Azuma. VSIG4/CRIg directly regulates early CD8(+) T cell activation through its counter-receptor in a narrow window. Biochem Biophys Res Commun, 614:100-106, 2022. DOI:1016/j.bbrc.2022.04.120
   
   
2. Y Tamura, K Yamane, Y Kawano, L Bullinger, T Wirtz, T Weber, S Sander, S Ohki, Y Kitajima, S Okada, K Rajewsky and T Yasuda. Concomitant Cytotoxic Effector Differentiation of CD4(+) and CD8(+) T Cells in Response to EBV-Infected B Cells. Cancers, 14:10.3390/cancers14174118, 2022. DOI:3390/cancers14174118
   
   
3. H Shiraki, S Tanaka, Y Guo, K Harada, I Hide, T Yasuda and N Sakai. Potential role of inducible GPR3 expression under stimulated T cell conditions. J Pharmacol Sci, 148:307-314, 2022. DOI:1016/j.jphs.2022.01.005
   
   
4. S Osana, Y Kitajima, S Naoki, H Takada, K Murayama, Y Kano and R Nagatomi. Little involvement of recycled-amino acids from proteasomal proteolysis in de novo protein synthesis. Biochem Biophys Res Commun, 634:40-47, 2022. DOI:1016/j.bbrc.2022.09.113
   
   
5. S Mise, A Matsumoto, K Shimada, T Hosaka, M Takahashi, K Ichihara, H Shimizu, C Shiraishi, D Saito, M Suyama, T Yasuda, T Ide, Y Izumi, T Bamba, T Kimura-Someya, M Shirouzu, H Miyata, M Ikawa and KI Nakayama. Kastor and Polluks polypeptides encoded by a single gene locus cooperatively regulate VDAC and spermatogenesis. Nat Commun, 13:1071, 2022. DOI:1038/s41467-022-28677-y
   
   
6. Y Kitajima, R Tsukahara, S Nakamoto and T Yasuda. Efficient Isolation of Lymphocytes and Myogenic Cells from the Tissue of Muscle Regeneration. Cells, 11:10.3390/cells11111754, 2022. DOI:3390/cells11111754

1. 2021
2. K Yoshioka, H Nagahisa, F Miura, H Araki, Y Kamei, Y Kitajima, D Seko, J Nogami, Y Tsuchiya, N Okazaki, A Yonekura, S Ohba, Y Sumita, K Chiba, K Ito, I Asahina, Y Ogawa, T Ito, Y Ohkawa and Y Ono. Hoxa10 mediates positional memory to govern stem cell function in adult skeletal muscle. Sci Adv, 7:10.1126/sciadv.abd7924, 2021. DOI:1126/sciadv.abd7924
   
   
3. K Yoshioka, Y Kitajima, D Seko, Y Tsuchiya and Y Ono. The body region specificity in murine models of muscle regeneration and atrophy. Acta Physiol, 231:e13553, 2021. DOI:1111/apha.13553
   
   
4. T Yasuda, Y Saito, C Ono, K Kawata, A Baba and Y Baba. Generation and characterization of CD19-iCre mice as a tool for efficient and specific conditional gene targeting in B cells. Sci Rep, 11:5524, 2021. DOI:1038/s41598-021-84786-6
   
   
5. N Tsugawa, D Yamada, T Watabe, M Onizawa, S Wang, Y Nemoto, S Oshima, T Tsubata, T Adachi, Y Kawano, M Watanabe, RS Blumberg, R Okamoto and T Nagaishi. CEACAM1 specifically suppresses B cell receptor signaling-mediated activation. Biochem Biophys Res Commun, 535:99-105, 2021. DOI:1016/j.bbrc.2020.11.126
   
   
6. T Sakurai, M Kukimoto-Niino, K Kunimura, N Yamane, D Sakata, R Aihara, T Yasuda, S Yokoyama, M Shirouzu, Y Fukui and T Uruno. A conserved PI(4,5)P2-binding domain is critical for immune regulatory function of DOCK8. Life Sci Alliance, 4:10.26508/lsa.202000873, 2021. DOI:26508/lsa.202000873
   
   
7. S Osana, Y Kitajima, N Suzuki, A Nunomiya, H Takada, T Kubota, K Murayama and R Nagatomi. Puromycin-sensitive aminopeptidase is required for C2C12 myoblast proliferation and differentiation. J Cell Physiol, 236:5293-5305, 2021. DOI:1002/jcp.30237
   
   
8. A Nita, A Matsumoto, R Tang, C Shiraishi, K Ichihara, D Saito, M Suyama, T Yasuda, G Tsuji, M Furue, B Katayama, T Ozawa, T Murata, T Dainichi, K Kabashima, A Hatano, M Matsumoto and KI Nakayama. A ubiquitin-like protein encoded by the "noncoding" RNA TINCR promotes keratinocyte proliferation and wound healing. PLoS Genet, 17:e1009686, 2021. DOI:1371/journal.pgen.1009686
   
   
9. WS Kong, N Tsuyama, H Inoue, Y Guo, S Mokuda, A Nobukiyo, N Nakatani, F Yamaide, T Nakano, Y Kohno, K Ikeda, Y Nakanishi, H Ohno, M Arita, N Shimojo and M Kanno. Long-chain saturated fatty acids in breast milk are associated with the pathogenesis of atopic dermatitis via induction of inflammatory ILC3s. Sci Rep, 11:13109, 2021. DOI:1038/s41598-021-92282-0
   
   
10. S Huang and T Yasuda. Pathologically Relevant Mouse Models for Epstein-Barr Virus-Associated B Cell Lymphoma. Front Immunol, 12:639844, 2021. DOI:3389/fimmu.2021.639844

1. 2020
2. K Yoshioka, Y Kitajima, N Okazaki, K Chiba, A Yonekura and Y Ono. A Modified Pre-plating Method for High-Yield and High-Purity Muscle Stem Cell Isolation From Human/Mouse Skeletal Muscle Tissues. Front Cell Dev Biol, 8:793, 2020. DOI:3389/fcell.2020.00793
   
   
3. Y Yang, S Nagai, S Kang, Y Xia, Y Kawano, K Miyake, H Karasuyama and M Azuma. Tolerogenic properties of CD206+ macrophages appeared in the sublingual mucosa after repeated antigen-painting. Int Immunol, 32:509-518, 2020. DOI:1093/intimm/dxaa014
   
   
4. Y Tsuchiya, Y Kitajima, H Masumoto and Y Ono. Damaged Myofiber-Derived Metabolic Enzymes Act as Activators of Muscle Satellite Cells. Stem Cell Reports, 15:926-940, 2020. DOI:1016/j.stemcr.2020.08.002
   
   
5. T Sommermann, T Yasuda, J Ronen, T Wirtz, T Weber, U Sack, R Caeser, J Zhang, X Li, VT Chu, A Jauch, K Unger, DJ Hodson, A Akalin and K Rajewsky. Functional interplay of Epstein-Barr virus oncoproteins in a mouse model of B cell lymphomagenesis. Proc Natl Acad Sci U S A, 117:14421-14432, 2020. DOI:1073/pnas.1921139117
   
   
6. S Osana, Y Kitajima, N Suzuki, Y Xu, K Murayama and R Nagatomi. siRNA knockdown of alanine aminopeptidase impairs myoblast proliferation and differentiation. Exp Cell Res, 397:112337, 2020. DOI:1016/j.yexcr.2020.112337
   
   
7. H Ono, N Suzuki, SI Kanno, G Kawahara, R Izumi, T Takahashi, Y Kitajima, S Osana, N Nakamura, T Akiyama, K Ikeda, T Shijo, S Mitsuzawa, R Nagatomi, N Araki, A Yasui, H Warita, YK Hayashi, K Miyake and M Aoki. AMPK Complex Activation Promotes Sarcolemmal Repair in Dysferlinopathy. Mol Ther, 28:1133-1153, 2020. DOI:1016/j.ymthe.2020.02.006
   
   
8. Y Kitajima, K Yoshioka and N Suzuki. The ubiquitin-proteasome system in regulation of the skeletal muscle homeostasis and atrophy: from basic science to disorders. J Physiol Sci, 70:40, 2020. DOI:1186/s12576-020-00768-9
   
   
9. Y Kitajima, N Suzuki, K Yoshioka, R Izumi, M Tateyama, Y Tashiro, R Takahashi, M Aoki and Y Ono. Inducible Rpt3, a Proteasome Component, Knockout in Adult Skeletal Muscle Results in Muscle Atrophy. Front Cell Dev Biol, 8:859, 2020. DOI:3389/fcell.2020.00859

1. 1997-2019
2. S Yoshikawa, M Oh-Hora, R Hashimoto, T Nagao, L Peters, M Egawa, T Ohta, K Miyake, T Adachi, Y Kawano, Y Yamanishi and H Karasuyama. Pivotal role of STIM2, but not STIM1, in IL-4 production by IL-3-stimulated murine basophils. Sci Signal, 12:10.1126/scisignal.aav2060, 2019. DOI:1126/scisignal.aav2060
   
   
3. T Nagao, Y Yamanishi, K Miyake, M Teranishi, S Takahashi, S Yoshikawa, Y Kawano and H Karasuyama. Aggregation makes a protein allergenic at the challenge phase of basophil-mediated allergy in mice. Int Immunol, 31:41-49, 2019. DOI:1093/intimm/dxy062
   
   
4. K Imami and T Yasuda. Measuring Protein Synthesis during Cell Cycle by Azidohomoalanine (AHA) Labeling and Flow Cytometric Analysis. Bio Protoc, 9:e3215, 2019. DOI:21769/BioProtoc.3215
   
   
5. T Akiyama, N Suzuki, M Ishikawa, K Fujimori, T Sone, J Kawada, R Funayama, F Fujishima, S Mitsuzawa, K Ikeda, H Ono, T Shijo, S Osana, M Shirota, T Nakagawa, Y Kitajima, A Nishiyama, R Izumi, S Morimoto, Y Okada, T Kamei, M Nishida, M Nogami, S Kaneda, Y Ikeuchi, H Mitsuhashi, K Nakayama, T Fujii, H Warita, H Okano and M Aoki. Aberrant axon branching via Fos-B dysregulation in FUS-ALS motor neurons. EBioMedicine, 45:362-378, 2019. DOI:1016/j.ebiom.2019.06.013
   
   
6. Y Tabakawa, T Ohta, S Yoshikawa, EJ Robinson, K Yamaji, K Ishiwata, Y Kawano, K Miyake, Y Yamanishi, H Ohtsu, T Adachi, N Watanabe, H Kanuka and H Karasuyama. Histamine Released From Skin-Infiltrating Basophils but Not Mast Cells Is Crucial for Acquired Tick Resistance in Mice. Front Immunol, 9:1540, 2018. DOI:3389/fimmu.2018.01540
   
   
7. T Shijo, H Warita, N Suzuki, Y Kitajima, K Ikeda, T Akiyama, H Ono, S Mitsuzawa, A Nishiyama, R Izumi and M Aoki. Aberrant astrocytic expression of chondroitin sulfate proteoglycan receptors in a rat model of amyotrophic lateral sclerosis. J Neurosci Res, 96:222-233, 2018. DOI:1002/jnr.24127
   
   
8. T Shijo, H Warita, N Suzuki, K Ikeda, S Mitsuzawa, T Akiyama, H Ono, A Nishiyama, R Izumi, Y Kitajima and M Aoki. Antagonizing bone morphogenetic protein 4 attenuates disease progression in a rat model of amyotrophic lateral sclerosis. Exp Neurol, 307:164-179, 2018. DOI:1016/j.expneurol.2018.06.009
   
   
9. G Petkau, Y Kawano, I Wolf, M Knoll and F Melchers. MiR221 promotes precursor B-cell retention in the bone marrow by amplifying the PI3K-signaling pathway in mice. Eur J Immunol, 48:975-989, 2018. DOI:1002/eji.201747354
   
   
10. Y Kitajima, N Suzuki, A Nunomiya, S Osana, K Yoshioka, Y Tashiro, R Takahashi, Y Ono, M Aoki and R Nagatomi. The Ubiquitin-Proteasome System Is Indispensable for the Maintenance of Muscle Stem Cells. Stem Cell Reports, 11:1523-1538, 2018. DOI:1016/j.stemcr.2018.10.009
    
    
11. Y Kitajima and Y Ono. Visualization of PAX7 protein dynamics in muscle satellite cells in a YFP knock-in-mouse line. Skelet Muscle, 8:26, 2018. DOI:1186/s13395-018-0174-x
    
    
12. Y Kawano, G Petkau, C Stehle, P Durek, GA Heinz, K Tanimoto, H Karasuyama, MF Mashreghi, C Romagnani and F Melchers. Stable lines and clones of long-term proliferating normal, genetically unmodified murine common lymphoid progenitors. Blood, 131:2026-2035, 2018. DOI:1182/blood-2017-09-805259
    
    
13. H Karasuyama, K Miyake, S Yoshikawa, Y Kawano and Y Yamanishi. How do basophils contribute to Th2 cell differentiation and allergic responses? Int Immunol, 30:391-396, 2018. DOI:1093/intimm/dxy026
    
    
14. K Imami, M Milek, B Bogdanow, T Yasuda, N Kastelic, H Zauber, Y Ishihama, M Landthaler and M Selbach. Phosphorylation of the Ribosomal Protein RPL12/uL11 Affects Translation during Mitosis. Mol Cell, 72:84-98 e89, 2018. DOI:1016/j.molcel.2018.08.019
    
    
15. VM Ho, N Hirohashi, WS Kong, G Yun, K Ota, J Itai, S Yamaga, K Suzuki, K Tanigawa, M Kanno and N Shime. Sera from Septic Patients Contain the Inhibiting Activity of the Extracellular ATP-Dependent Inflammasome Pathway. Tohoku J Exp Med, 245:193-204, 2018. DOI:1620/tjem.245.193
    
    
16. A Harada, K Maehara, Y Ono, H Taguchi, K Yoshioka, Y Kitajima, Y Xie, Y Sato, T Iwasaki, J Nogami, S Okada, T Komatsu, Y Semba, T Takemoto, H Kimura, H Kurumizaka and Y Ohkawa. Histone H3.3 sub-variant H3mm7 is required for normal skeletal muscle regeneration. Nat Commun, 9:1400, 2018. DOI:1038/s41467-018-03845-1
    
    
17. S Fujimaki, D Seko, Y Kitajima, K Yoshioka, Y Tsuchiya, S Masuda and Y Ono. Notch1 and Notch2 Coordinately Regulate Stem Cell Function in the Quiescent and Activated States of Muscle Satellite Cells. Stem Cells, 36:278-285, 2018. DOI:1002/stem.2743
    
    
18. J Tornack, Y Kawano, N Garbi, GJ Hammerling, F Melchers and M Tsuneto. Flt3 ligand-eGFP-reporter expression characterizes functionally distinct subpopulations of CD150(+) long-term repopulating murine hematopoietic stem cells. Eur J Immunol, 47:1477-1487, 2017. DOI:1002/eji.201646730
    
    
19. T Ohta, S Yoshikawa, Y Tabakawa, K Yamaji, K Ishiwata, H Shitara, C Taya, M Oh-Hora, Y Kawano, K Miyake, Y Yamanishi, H Yonekawa, N Watanabe, H Kanuka and H Karasuyama. Skin CD4(+) Memory T Cells Play an Essential Role in Acquired Anti-Tick Immunity through Interleukin-3-Mediated Basophil Recruitment to Tick-Feeding Sites. Front Immunol, 8:1348, 2017. DOI:3389/fimmu.2017.01348
    
    
20. A Nunomiya, J Shin, Y Kitajima, T Dan, T Miyata and R Nagatomi. Activation of the hypoxia-inducible factor pathway induced by prolyl hydroxylase domain 2 deficiency enhances the effect of running training in mice. Acta Physiol, 220:99-112, 2017. DOI:1111/apha.12751
    
    
21. Y Kawano, G Petkau, I Wolf, J Tornack and F Melchers. IL-7 and immobilized Kit-ligand stimulate serum- and stromal cell-free cultures of precursor B-cell lines and clones. Eur J Immunol 47:206-212, 2017. DOI:1002/eji.201646677
    
    
22. T Wirtz, T Weber, S Kracker, T Sommermann, K Rajewsky and T Yasuda. Mouse model for acute Epstein-Barr virus infection. Proc Natl Acad Sci U S A, 113:13821-13826, 2016. DOI:1073/pnas.1616574113
    
    
23. A Uruno, Y Yagishita, F Katsuoka, Y Kitajima, A Nunomiya, R Nagatomi, J Pi, SS Biswal and M Yamamoto. Nrf2-Mediated Regulation of Skeletal Muscle Glycogen Metabolism. Mol Cell Biol, 36:1655-1672, 2016. DOI:1128/MCB.01095-15
    
    
24. H Shinohara, T Yasuda and T Kurosaki. TAK1 adaptor proteins, TAB2 and TAB3, link the signalosome to B-cell receptor-induced IKK activation. FEBS Lett, 590:3264-3269, 2016. DOI:1002/1873-3468.12342
    
    
25. J Shin, A Nunomiya, Y Kitajima, T Dan, T Miyata and R Nagatomi. Prolyl hydroxylase domain 2 deficiency promotes skeletal muscle fiber-type transition via a calcineurin/NFATc1-dependent pathway. Skelet Muscle, 6:5, 2016. DOI:1186/s13395-016-0079-5
    
    
26. DJ Klionsky, ... Y Kitajima, ... and SM Zughaier. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy, 12:1-222, 2016. DOI:1080/15548627.2015.1100356
    
    
27. Y Kitajima, S Ogawa and Y Ono. Visualizing the Functional Heterogeneity of Muscle Stem Cells. Methods Mol Biol, 1516:183-193, 2016. DOI:1007/7651_2016_349
    
    
28. E Ishikawa, H Kosako, T Yasuda, M Ohmuraya, K Araki, T Kurosaki, T Saito and S Yamasaki. Protein kinase D regulates positive selection of CD4(+) thymocytes through phosphorylation of SHP-1. Nat Commun, 7:12756, 2016. DOI:1038/ncomms12756
    
    
29. E Derudder, S Herzog, V Labi, T Yasuda, K Kochert, M Janz, A Villunger, M Schmidt-Supprian and K Rajewsky. Canonical NF-kappaB signaling is uniquely required for the long-term persistence of functional mature B cells. Proc Natl Acad Sci U S A, 113:5065-5070, 2016. DOI:1073/pnas.1604529113
    
    
30. S Cho, CJ Wu, T Yasuda, LO Cruz, AA Khan, LL Lin, DT Nguyen, M Miller, HM Lee, ML Kuo, DH Broide, K Rajewsky, AY Rudensky and LF Lu. miR-23 approximately 27 approximately 24 clusters control effector T cell differentiation and function. J Exp Med, 213:235-249, 2016. DOI:1084/jem.20150990
    
    
31. T Yasuda. 2015. MAP kinase cascades in antigen receptor signaling and physiology. Current Topics in Microbiology and Immunology, 393, 2015. DOI:1007/82_2015_481
    
    
32. M Yamaya, Y Shimotai, Y Hatachi, N Lusamba Kalonji, Y Tando, Y Kitajima, K Matsuo, H Kubo, R Nagatomi, S Hongo, M Homma and H Nishimura. The serine protease inhibitor camostat inhibits influenza virus replication and cytokine production in primary cultures of human tracheal epithelial cells. Pulm Pharmacol Ther, 33:66-74, 2015. DOI:1016/j.pupt.2015.07.001
    
    
33. S Sander, VT Chu, T Yasuda, A Franklin, R Graf, DP Calado, S Li, K Imami, M Selbach, M Di Virgilio, L Bullinger and K Rajewsky. PI3 Kinase and FOXO1 Transcription Factor Activity Differentially Control B Cells in the Germinal Center Light and Dark Zones. Immunity, 43:1075-1086, 2015. DOI:1016/j.immuni.2015.10.021
    
    
34. Y Murakawa, M Hinz, J Mothes, A Schuetz, M Uhl, E Wyler, T Yasuda, G Mastrobuoni, CC Friedel, L Dolken, S Kempa, M Schmidt-Supprian, N Bluthgen, R Backofen, U Heinemann, J Wolf, C Scheidereit and M Landthaler. RC3H1 post-transcriptionally regulates A20 mRNA and modulates the activity of the IKK/NF-kappaB pathway. Nat Commun, 6:7367, 2015. DOI:1038/ncomms8367
    
    
35. S Mokuda, T Miyazaki, Y Ito, S Yamasaki, H Inoue, Y Guo, WS Kong, M Kanno, K Takasugi, E Sugiyama and J Masumoto. The proto-oncogene survivin splice variant 2B is induced by PDGF and leads to cell proliferation in rheumatoid arthritis fibroblast-like synoviocytes. Sci Rep, 5:9795, 2015. DOI:1038/srep09795
    
    
36. L LiHua, S Yoshikawa, T Ohta, K Horiguchi, Y Kawano, H Ohtsu, Y Yamanishi and H Karasuyama. Large particulate allergens can elicit mast cell-mediated anaphylaxis without exit from blood vessels as efficiently as do small soluble allergens. Biochem Biophys Res Commun, 467:70-75, 2015. DOI:1016/j.bbrc.2015.09.120
    
    
37. S Yasukawa, Y Miyazaki, C Yoshii, M Nakaya, N Ozaki, S Toda, E Kuroda, K Ishibashi, T Yasuda, Y Natsuaki, F Mi-ichi, E Iizasa, T Nakahara, M Yamazaki, K Kabashima, Y Iwakura, T Takai, T Saito, T Kurosaki, B Malissen, N Ohno, M Furue, H Yoshida and H Hara. An ITAM-Syk-CARD9 signalling axis triggers contact hypersensitivity by stimulating IL-1 production in dendritic cells. Nat Commun, 5:3755, 2014. DOI:1038/ncomms4755
    
    
38. H Shinohara, M Behar, K Inoue, M Hiroshima, T Yasuda, T Nagashima, S Kimura, H Sanjo, S Maeda, N Yumoto, S Ki, S Akira, Y Sako, A Hoffmann, T Kurosaki and M Okada-Hatakeyama. Positive feedback within a kinase signaling complex functions as a switch mechanism for NF-kappaB activation. Science, 344:760-764, 2014. DOI:1126/science.1250020
    
    
39. Y Kitajima, Y Tashiro, N Suzuki, H Warita, M Kato, M Tateyama, R Ando, R Izumi, M Yamazaki, M Abe, K Sakimura, H Ito, M Urushitani, R Nagatomi, R Takahashi and M Aoki. Proteasome dysfunction induces muscle growth defects and protein aggregation. J Cell Sci, 127:5204-5217, 2014. DOI:1242/jcs.150961
    
    
40. T Yasuda, T Wirtz, B Zhang, T Wunderlich, M Schmidt-Supprian, T Sommermann and K Rajewsky. Studying Epstein-Barr virus pathologies and immune surveillance by reconstructing EBV infection in mice. Cold Spring Harb Symp Quant Biol, 78:259-263, 2013. DOI:1101/sqb.2013.78.020222
    
    
41. K Obata-Ninomiya, K Ishiwata, H Tsutsui, Y Nei, S Yoshikawa, Y Kawano, Y Minegishi, N Ohta, N Watanabe, H Kanuka and H Karasuyama. The skin is an important bulwark of acquired immunity against intestinal helminths. J Exp Med, 210:2583-2595, 2013. DOI:1084/jem.20130761
    
    
42. A Farmawati, Y Kitajima, T Nedachi, M Sato, M Kanzaki and R Nagatomi. Characterization of contraction-induced IL-6 up-regulation using contractile C2C12 myotubes. Endocr J, 60:137-147, 2013. DOI:1507/endocrj.ej12-0316
    
    
43. M Egawa, K Mukai, S Yoshikawa, M Iki, N Mukaida, Y Kawano, Y Minegishi and H Karasuyama. Inflammatory monocytes recruited to allergic skin acquire an anti-inflammatory M2 phenotype via basophil-derived interleukin-4. Immunity, 38:570-580, 2013. DOI:1016/j.immuni.2012.11.014
    
    
44. B Zhang, S Kracker, T Yasuda, S Casola, M Vanneman, C Homig-Holzel, Z Wang, E Derudder, S Li, T Chakraborty, SE Cotter, S Koyama, T Currie, GJ Freeman, JL Kutok, SJ Rodig, G Dranoff and K Rajewsky. Immune surveillance and therapy of lymphomas driven by Epstein-Barr virus protein LMP1 in a mouse model. Cell, 148:739-751, 2012. DOI:1016/j.cell.2011.12.031
    
    
45. H Ogawa, K Mukai, Y Kawano, Y Minegishi and H Karasuyama. Th2-inducing cytokines IL-4 and IL-33 synergistically elicit the expression of transmembrane TNF-alpha on macrophages through the autocrine action of IL-6. Biochem Biophys Res Commun, 420:114-118, 2012. DOI:1016/j.bbrc.2012.02.124
    
    
46. Y Kawano, R Ouchida, JY Wang, S Yoshikawa, M Yamamoto, D Kitamura and H Karasuyama. A novel mechanism for the autonomous termination of pre-B cell receptor expression via induction of lysosome-associated protein transmembrane 5. Mol Cell Biol, 32:4462-4471, 2012. DOI:1128/MCB.00531-12
    
    
47. T Yasuda, K Kometani, N Takahashi, Y Imai, Y Aiba and T Kurosaki. ERKs induce expression of the transcriptional repressor Blimp-1 and subsequent plasma cell differentiation. Sci Signal, 4:ra25, 2011. DOI:1126/scisignal.2001592
    
    
48. H Yamagishi, Y Mochizuki, T Hamakubo, K Obata, T Ugajin, S Sato, Y Kawano, Y Minegishi and H Karasuyama. Basophil-derived mouse mast cell protease 11 induces microvascular leakage and tissue edema in a mast cell-independent manner. Biochem Biophys Res Commun, 415:709-713, 2011. DOI:1016/j.bbrc.2011.10.150
    
    
49. H Nishikado, K Mukai, Y Kawano, Y Minegishi and H Karasuyama. NK cell-depleting anti-asialo GM1 antibody exhibits a lethal off-target effect on basophils in vivo. J Immunol, 186:5766-5771, 2011. DOI:4049/jimmunol.1100370
    
    
50. T Wada, K Ishiwata, H Koseki, T Ishikura, T Ugajin, N Ohnuma, K Obata, R Ishikawa, S Yoshikawa, K Mukai, Y Kawano, Y Minegishi, H Yokozeki, N Watanabe and H Karasuyama. Selective ablation of basophils in mice reveals their nonredundant role in acquired immunity against ticks. J Clin Invest, 120:2867-2875, 2010. DOI:1172/JCI42680
    
    
51. S Kuchen, W Resch, A Yamane, N Kuo, Z Li, T Chakraborty, L Wei, A Laurence, T Yasuda, S Peng, J Hu-Li, K Lu, W Dubois, Y Kitamura, N Charles, HW Sun, S Muljo, PL Schwartzberg, WE Paul, J O'Shea, K Rajewsky and R Casellas. Regulation of microRNA expression and abundance during lymphopoiesis. Immunity, 32:828-839, 2010. DOI:1016/j.immuni.2010.05.009
    
    
52. R Ishikawa, Y Tsujimura, K Obata, Y Kawano, Y Minegishi and H Karasuyama. IgG-mediated systemic anaphylaxis to protein antigen can be induced even under conditions of limited amounts of antibody and antigen. Biochem Biophys Res Commun, 402:742-746, 2010. DOI:1016/j.bbrc.2010.10.098
    
    
53. S Yoshikawa, Y Kawano, Y Minegishi and H Karasuyama. The skewed heavy-chain repertoire in peritoneal B-1 cells is predetermined by the selection via pre-B cell receptor during B cell ontogeny in the fetal liver. Int Immunol, 21:43-52, 2009. DOI:1093/intimm/dxn122
    
    
54. T Ugajin, T Kojima, K Mukai, K Obata, Y Kawano, Y Minegishi, Y Eishi, H Yokozeki and H Karasuyama. Basophils preferentially express mouse Mast Cell Protease 11 among the mast cell tryptase family in contrast to mast cells. J Leukoc Biol, 86:1417-1425, 2009. DOI:1189/jlb.0609400
    
    
55. T Yasuda, H Sanjo, G Pages, Y Kawano, H Karasuyama, J Pouyssegur, M Ogata and T Kurosaki. Erk kinases link pre-B cell receptor signaling to transcriptional events required for early B cell expansion. Immunity, 28:499-508, 2008. DOI:1016/j.immuni.2008.02.015
    
    
56. T Yasuda and T Kurosaki. Regulation of lymphocyte fate by Ras/ERK signals. Cell Cycle, 7:3634-3640, 2008. DOI:4161/cc.7.23.7103
    
    
57. Y Tsujimura, K Obata, K Mukai, H Shindou, M Yoshida, H Nishikado, Y Kawano, Y Minegishi, T Shimizu and H Karasuyama. Basophils play a pivotal role in immunoglobulin-G-mediated but not immunoglobulin-E-mediated systemic anaphylaxis. Immunity, 28:581-589, 2008. DOI:1016/j.immuni.2008.02.008
    
    
58. T Hosooka, T Noguchi, K Kotani, T Nakamura, H Sakaue, H Inoue, W Ogawa, K Tobimatsu, K Takazawa, M Sakai, Y Matsuki, R Hiramatsu, T Yasuda, MA Lazar, Y Yamanashi and M Kasuga. Dok1 mediates high-fat diet-induced adipocyte hypertrophy and obesity through modulation of PPAR-gamma phosphorylation. Nat Med, 14:188-193, 2008. DOI:1038/nm1706
    
    
59. T Yasuda, K Bundo, A Hino, K Honda, A Inoue, M Shirakata, M Osawa, T Tamura, H Nariuchi, H Oda, T Yamamoto and Y Yamanashi. Dok-1 and Dok-2 are negative regulators of T cell receptor signaling. Int Immunol, 19:487-495, 2007. DOI:1093/intimm/dxm015
    
    
60. K Obata, K Mukai, Y Tsujimura, K Ishiwata, Y Kawano, Y Minegishi, N Watanabe and H Karasuyama. Basophils are essential initiators of a novel type of chronic allergic inflammation. Blood, 110:913-920, 2007. DOI:1182/blood-2007-01-068718
    
    
61. Y Matsubara, I Kawasaki, S Urushiyama, T Yasuda, M Shirakata, Y Iino, H Shibuya and Y Yamanashi. The adaptor-like protein ROG-1 is required for activation of the Ras-MAP kinase pathway and meiotic cell cycle progression in Caenorhabditis elegans. Genes Cells, 12:407-420, 2007. DOI:1111/j.1365-2443.2007.01061.x
    
    
62. A Inoue, T Yasuda, T Yamamoto and Y Yamanashi. Dok-1 is a positive regulator of IL-4 signalling and IgE response. J Biochem, 142:257-263, 2007. DOI:1093/jb/mvm127
    
    
63. M Yamamoto, K Hayashi, T Nojima, Y Matsuzaki, Y Kawano, H Karasuyama, R Goitsuka and D Kitamura. BASH-novel PKC-Raf-1 pathway of pre-BCR signaling induces kappa gene rearrangement. Blood, 108:2703-2711, 2006. DOI:1182/blood-2006-05-024968
    
    
64. Y Kawano, S Yoshikawa, Y Minegishi and H Karasuyama. Pre-B cell receptor assesses the quality of IgH chains and tunes the pre-B cell repertoire by delivering differential signals. J Immunol, 177:2242-2249, 2006. DOI:4049/jimmunol.177.4.2242
    
    
65. M Honma, O Higuchi, M Shirakata, T Yasuda, H Shibuya, S Iemura, T Natsume and Y Yamanashi. Dok-3 sequesters Grb2 and inhibits the Ras-Erk pathway downstream of protein-tyrosine kinases. Genes Cells, 11:143-151, 2006. DOI:1111/j.1365-2443.2006.00926.x
    
    
66. H Shinohara, T Yasuda, Y Aiba, H Sanjo, M Hamadate, H Watarai, H Sakurai and T Kurosaki. PKC beta regulates BCR-mediated IKK activation by facilitating the interaction between TAK1 and CARMA1. J Exp Med, 202:1423-1431, 2005. DOI:1084/jem.20051591
    
    
67. H Shinohara, A Inoue, N Toyama-Sorimachi, Y Nagai, T Yasuda, H Suzuki, R Horai, Y Iwakura, T Yamamoto, H Karasuyama, K Miyake and Y Yamanashi. Dok-1 and Dok-2 are negative regulators of lipopolysaccharide-induced signaling. J Exp Med, 201:333-339, 2005. DOI:1084/jem.20041817
    
    
68. Y Kawano, S Yoshikawa, Y Minegishi and H Karasuyama. Selection of stereotyped VH81X-microH chains via pre-B cell receptor early in ontogeny and their conservation in adults by marginal zone B cells. Int Immunol, 17:857-867, 2005. DOI:1093/intimm/dxh265
    
    
69. Y Katakura, K Yoshizaki, T Yasuda, T Tsunematsu, N Uehara, T Miura, T Fujiki and S Shirahata. Functional impairment of telomerase in sublines derived from human lung adenocarcinoma exposed to mild oxidative stress. Biochem Biophys Res Commun, 334:450-459, 2005. DOI:1016/j.bbrc.2005.06.109
    
    
70. T Yasuda and T Yamamoto. Analysis of B-cell signaling using DT40 B-cell line. Methods Mol Biol, 271:261-270, 2004. DOI:1385/1-59259-796-3:261
    
    
71. T Yasuda, M Shirakata, A Iwama, A Ishii, Y Ebihara, M Osawa, K Honda, H Shinohara, K Sudo, K Tsuji, H Nakauchi, Y Iwakura, H Hirai, H Oda, T Yamamoto and Y Yamanashi. Role of Dok-1 and Dok-2 in myeloid homeostasis and suppression of leukemia. J Exp Med, 200:1681-1687, 2004. DOI:1084/jem.20041247
    
    
72. H Shinohara, T Yasuda and Y Yamanashi. Dok-1 tyrosine residues at 336 and 340 are essential for the negative regulation of Ras-Erk signalling, but dispensable for rasGAP-binding. Genes Cells, 9:601-607, 2004. DOI:1111/j.1356-9597.2004.00748.x
    
    
73. K Tsuchiya, Y Kawano, T Kojima, K Nagata, T Takao, M Okada, H Shinohara, K Maki, N Toyama-Sorimachi, N Miyasaka, M Watanabe and H Karasuyama. Molecular cloning and characterization of TPP36 and its isoform TPP32, novel substrates of Abl tyrosine kinase. FEBS Lett, 537:203-209, 2003. DOI:1016/s0014-5793(03)00127-3
    
    
74. K Yokoyama, IH Su Ih, T Tezuka, T Yasuda, K Mikoshiba, A Tarakhovsky and T Yamamoto. BANK regulates BCR-induced calcium mobilization by promoting tyrosine phosphorylation of IP(3) receptor. EMBO J, 21:83-92, 2002. DOI:1093/emboj/21.1.83
    
    
75. T Yasuda, T Tezuka, A Maeda, T Inazu, Y Yamanashi, H Gu, T Kurosaki and T Yamamoto. Cbl-b positively regulates Btk-mediated activation of phospholipase C-gamma2 in B cells. J Exp Med, 196:51-63, 2002. DOI:1084/jem.20020068
    
    
76. M Magari, T Sawatari, Y Kawano, M Cascalho, M Wabl, N Kanayama, M Hikida and H Ohmori. Contribution of light chain rearrangement in peripheral B cells to the generation of high-affinity antibodies. Eur J Immunol, 32:957-966, 2002. DOI:1002/1521-4141(200204)32:4<957::AID-IMMU957>3.0.CO;2-A
    
    
77. T Yasuda, A Maeda, M Kurosaki, T Tezuka, K Hironaka, T Yamamoto and T Kurosaki. Cbl suppresses B cell receptor-mediated phospholipase C (PLC)-gamma2 activation by regulating B cell linker protein-PLC-gamma2 binding. J Exp Med, 191:641-650, 2000. DOI:1084/jem.191.4.641
    
    
78. Y Katakura, K Yamamoto, O Miyake, T Yasuda, N Uehara, E Nakata, S Kawamoto and S Shirahata. Bidirectional regulation of telomerase activity in a subline derived from human lung adenocarcinoma. Biochem Biophys Res Commun, 237:313-317, 1997. DOI:1006/bbrc.1997.7104