HIROSHIMA UNIVERSITY

Department of Immunology,
Graduate School of Biomedical and Health Sciences

業績

Selected papers

 

◎ Y Kitajima, N Suzuki, A Nunomiya, S Osana, K Yoshioka, Y Tashiro, R Takahashi, Y Ono, M Aoki and R Nagatomi. The Ubiquitin-Proteasome System Is Indispensable for the Maintenance of Muscle Stem Cells. Stem Cell Reports, 11:1523-1538, 2018. DOI:10.1016/j.stemcr.2018.10.009

 

◎ Y Kawano, G Petkau, C Stehle, P Durek, GA Heinz, K Tanimoto, H Karasuyama, MF Mashreghi, C Romagnani and F Melchers. Stable lines and clones of long-term proliferating normal, genetically unmodified murine common lymphoid progenitors. Blood, 131:2026-2035, 2018. DOI:10.1182/blood-2017-09-805259

 

◎ T Wirtz, T Weber, S Kracker, T Sommermann, K Rajewsky and T Yasuda. Mouse model for acute Epstein-Barr virus infection. Proc Natl Acad Sci U S A, 113:13821-13826, 2016. DOI:10.1073/pnas.1616574113

 

◎ B Zhang, S Kracker, T Yasuda, S Casola, M Vanneman, C Homig-Holzel, Z Wang, E Derudder, S Li, T Chakraborty, SE Cotter, S Koyama, T Currie, GJ Freeman, JL Kutok, SJ Rodig, G Dranoff and K Rajewsky. Immune surveillance and therapy of lymphomas driven by Epstein-Barr virus protein LMP1 in a mouse model. Cell, 148:739-751, 2012. DOI:10.1016/j.cell.2011.12.031

 

◎ T Yasuda, H Sanjo, G Pages, Y Kawano, H Karasuyama, J Pouyssegur, M Ogata and T Kurosaki. Erk kinases link pre-B cell receptor signaling to transcriptional events required for early B cell expansion. Immunity, 28:499-508, 2008. DOI:10.1016/j.immuni.2008.02.015

 

◎ T Yasuda, M Shirakata, A Iwama, A Ishii, Y Ebihara, M Osawa, K Honda, H Shinohara, K Sudo, K Tsuji, H Nakauchi, Y Iwakura, H Hirai, H Oda, T Yamamoto and Y Yamanashi. Role of Dok-1 and Dok-2 in myeloid homeostasis and suppression of leukemia. J Exp Med, 200:1681-1687, 2004. DOI:10.1084/jem.20041247

 

2025

  1. Jin, Y., Guo, Y., Kawano, Y., Sasatani, M., Ohki, S., Yamane, K., Ota, Y., Tamura, Y., Sotomaru, Y., Baba, Y., and Yasuda, T. T cell-mediated immune surveillance conferred by latent Epstein-Barr virus genes suppresses a broad spectrum of tumor formation through NKG2D-NKG2DL interactions. Front Immunol, 2025. in press

 

Tamura, Y., Ohki, S., Nagai, H., Yoshizato, R., Nishi, S., Jin, Y., Kitajima, Y., Guo, Y., Ichinohe, T., Okada, S., Kawano, Y., Yasuda, T. Co-expression of B7-H3 and LAG3 represents cytotoxicity of CD4+ T cells in humans. Front Immunol, 16, 2025. DOI:10.3389/fimmu.2025.1560383

 

  1. Sultana, F., A. Widyagarini, Y. Kawano, Y. Ohsugi, S. Katagiri, M. Azuma, and S. Nagai. Sublingual Macrophage-Associated Ildr2 Contributes to Immune Tolerance Via Treg Induction. Biochem Biophys Res Commun 742, 2025: 151009. DOI:10.1016/j.bbrc.2024.151009

 

2024

  1. Yoshizato, R., Miura, M., Shitaoka, K., Matsuoka, Y., Higashiura, A., Yamamoto, A., Guo, Y., Azuma, H., Kawano, Y., Ohga, S., and Yasuda, T. Comprehensive method for producing high-affinity mouse monoclonal antibodies of various isotypes against (4-hydroxy-3-nitrophenyl)acetyl (NP) hapten. Heliyon, 10, e40837, 2024. DOI:1016/j.heliyon.2024.e40837

 

  1. Kitajima Y, Yoshioka K, Mikumo Y, Ohki S, Maehara K, Ohkawa Y, Ono Y. Loss of Tob1 promotes muscle regeneration through muscle stem cell expansion. J Cell Sci. 2024. DOI: 1242/jcs.261886

 

  1. Guo, Y., Ohki, S., Kawano, Y., Kong, W.S., Ohno, Y., Honda, H., Kanno, M., and Yasuda, T. Eed-dependent histone modification orchestrates the iNKT cell developmental program alleviating liver injury. Front Immunol, 15, 1467774, 2024. DOI:10.3389/fimmu.2024.1467774

 

  1. Li, X., Wirtz, T., Weber, T., Lebedin, M., Lowenstein, E.D., Sommermann, T., Zach, A., Yasuda, T., de la Rosa, K., Chu, V.T., Schulte, J.H., Müller, I., Kocks, C., and Rajewsky, K. Precise CRISPR-Cas9 gene repair in autologous memory T cells to treat familial hemophagocytic lymphohistiocytosis. Sci Immunol, 9, eadi0042, 2024. DOI:10.1126/sciimmunol.adi0042

 

  1. 2023
  2. Jani, P. K., G. Petkau, Y. Kawano, U. Klemm, G. M. Guerra, G. A. Heinz, F. Heinrich, P. Durek, M. F. Mashreghi, and F. Melchers. The Mir-221/222 Cluster Regulates Hematopoietic Stem Cell Quiescence and Multipotency by Suppressing Both Fos/Ap-1/Ieg Pathway Activation and Stress-Like Differentiation to Granulocytes. PLoS Biol 21, no. 11, 2023: e3002015. DOI:10.1371/journal.pbio.3002015

 

  1. Osana S, Kitajima Y, Suzuki N, Murayama K, Takada H, Tabuchi A, Kano Y, Nagatomi R. The aminopeptidase LAP3 suppression accelerates myogenic differentiation via the AKT-TFE3 pathway in C2C12 myoblasts. J Cell Physiol, DOI:10.1002/jcp.31070

 

  1. K Inoue, T Yasuda, Y Baba, T Yamamoto, T Kurosaki and H Shinohara. Regulation mechanisms of CARMA1-Bcl10-MALT1 complex assembly inferred from the analysis of TRAF6-deficient cells. Genes Cells, 2023. DOI:1111/gtc.13022

  2. Yoshiyama, H., Nanbo, A., and Yasuda, T. How should we deal with neoplastic disease and serious infections caused by Epstein-Barr virus? Cancers, 15, 2889, 2023. DOI:3390/cancers15112889

 

  1. Shitaoka, K., Higashiura, A., Kawano, Y., Yamamoto, A., Mizoguchi, Y., Hashiguchi, T., Nishimichi, N., Huang, S., Ito, A., Ohki, S., Kanda, M., Taniguchi, T., Yoshizato, R., Azuma, H., Kitajima, Y., Yokosaki, Y., Okada, S., Sakaguchi, T., and Yasuda, T. Structural basis of spike RBM-specific human antibodies counteracting broad SARS-CoV-2 variants. Commun Biol, 6, 395, 2023. DOI:1038/s42003-023-04782-6

 

  1. H Azuma, Y Kawano, K Shitaoka, T Kawahara, A Ito, A Higashiura, Y Kitajima, S Ohki and T Yasuda. Vaccination with the Omicron spike RBD boosts broadly neutralizing antibody levels and confers sustained protection even after acquiring immunity to the original antigen. Int Immunol, 35:197-207, 2023. DOI:1093/intimm/dxac055

 

  1. Y Sugiyama, T Harada, Y Kamei, T Yasuda, T Mashimo, A Nishikimi and M Maruyama. A senolytic immunotoxin eliminates p16(INK4a)-positive T cells and ameliorates age-associated phenotypes of CD4(+) T cells in a surface marker knock-in mouse. Exp Gerontol, 174:112130, 2023. DOI:1016/j.exger.2023.112130

  2. W Winkler, C Farre Diaz, E Blanc, H Napieczynska, P Langner, M Werner, B Walter, B Wollert-Wulf, T Yasuda, A Heuser, D Beule, S Mathas, I Anagnostopoulos, A Rosenwald, K Rajewsky and M Janz. Mouse models of human multiple myeloma subgroups. Proc Natl Acad Sci U S A, 120:e2219439120, 2023. DOI:1073/pnas.2219439120

  3. K Hirano, M Tsuchiya, A Shiomi, S Takabayashi, M Suzuki, Y Ishikawa, Y Kawano, Y Takabayashi, K Nishikawa, K Nagao, E Umemoto, Y Kitajima, Y Ono, K Nonomura, H Shintaku, Y Mori, M Umeda and Y Hara. The mechanosensitive ion channel PIEZO1 promotes satellite cell function in muscle regeneration. Life Sci Alliance, 6:10.26508/lsa.202201783, 2023. DOI:26508/lsa.202201783

 

2022

  1. A Widyagarini, N Nishii, Y Kawano, C Zhang and M Azuma. VSIG4/CRIg directly regulates early CD8(+) T cell activation through its counter-receptor in a narrow window. Biochem Biophys Res Commun, 614:100-106, 2022. DOI:1016/j.bbrc.2022.04.120

  2. Y Tamura, K Yamane, Y Kawano, L Bullinger, T Wirtz, T Weber, S Sander, S Ohki, Y Kitajima, S Okada, K Rajewsky and T Yasuda. Concomitant Cytotoxic Effector Differentiation of CD4(+) and CD8(+) T Cells in Response to EBV-Infected B Cells. Cancers, 14:10.3390/cancers14174118, 2022. DOI:3390/cancers14174118

  3. H Shiraki, S Tanaka, Y Guo, K Harada, I Hide, T Yasuda and N Sakai. Potential role of inducible GPR3 expression under stimulated T cell conditions. J Pharmacol Sci, 148:307-314, 2022. DOI:1016/j.jphs.2022.01.005

  4. S Osana, Y Kitajima, S Naoki, H Takada, K Murayama, Y Kano and R Nagatomi. Little involvement of recycled-amino acids from proteasomal proteolysis in de novo protein synthesis. Biochem Biophys Res Commun, 634:40-47, 2022. DOI:1016/j.bbrc.2022.09.113

  5. S Mise, A Matsumoto, K Shimada, T Hosaka, M Takahashi, K Ichihara, H Shimizu, C Shiraishi, D Saito, M Suyama, T Yasuda, T Ide, Y Izumi, T Bamba, T Kimura-Someya, M Shirouzu, H Miyata, M Ikawa and KI Nakayama. Kastor and Polluks polypeptides encoded by a single gene locus cooperatively regulate VDAC and spermatogenesis. Nat Commun, 13:1071, 2022. DOI:1038/s41467-022-28677-y

  6. Y Kitajima, R Tsukahara, S Nakamoto and T Yasuda. Efficient Isolation of Lymphocytes and Myogenic Cells from the Tissue of Muscle Regeneration. Cells, 11:10.3390/cells11111754, 2022. DOI:3390/cells11111754

 

  1. 2021
  2. K Yoshioka, H Nagahisa, F Miura, H Araki, Y Kamei, Y Kitajima, D Seko, J Nogami, Y Tsuchiya, N Okazaki, A Yonekura, S Ohba, Y Sumita, K Chiba, K Ito, I Asahina, Y Ogawa, T Ito, Y Ohkawa and Y Ono. Hoxa10 mediates positional memory to govern stem cell function in adult skeletal muscle. Sci Adv, 7:10.1126/sciadv.abd7924, 2021. DOI:1126/sciadv.abd7924

  3. K Yoshioka, Y Kitajima, D Seko, Y Tsuchiya and Y Ono. The body region specificity in murine models of muscle regeneration and atrophy. Acta Physiol, 231:e13553, 2021. DOI:1111/apha.13553

  4. T Yasuda, Y Saito, C Ono, K Kawata, A Baba and Y Baba. Generation and characterization of CD19-iCre mice as a tool for efficient and specific conditional gene targeting in B cells. Sci Rep, 11:5524, 2021. DOI:1038/s41598-021-84786-6

  5. N Tsugawa, D Yamada, T Watabe, M Onizawa, S Wang, Y Nemoto, S Oshima, T Tsubata, T Adachi, Y Kawano, M Watanabe, RS Blumberg, R Okamoto and T Nagaishi. CEACAM1 specifically suppresses B cell receptor signaling-mediated activation. Biochem Biophys Res Commun, 535:99-105, 2021. DOI:1016/j.bbrc.2020.11.126

  6. T Sakurai, M Kukimoto-Niino, K Kunimura, N Yamane, D Sakata, R Aihara, T Yasuda, S Yokoyama, M Shirouzu, Y Fukui and T Uruno. A conserved PI(4,5)P2-binding domain is critical for immune regulatory function of DOCK8. Life Sci Alliance, 4:10.26508/lsa.202000873, 2021. DOI:26508/lsa.202000873

  7. S Osana, Y Kitajima, N Suzuki, A Nunomiya, H Takada, T Kubota, K Murayama and R Nagatomi. Puromycin-sensitive aminopeptidase is required for C2C12 myoblast proliferation and differentiation. J Cell Physiol, 236:5293-5305, 2021. DOI:1002/jcp.30237

  8. A Nita, A Matsumoto, R Tang, C Shiraishi, K Ichihara, D Saito, M Suyama, T Yasuda, G Tsuji, M Furue, B Katayama, T Ozawa, T Murata, T Dainichi, K Kabashima, A Hatano, M Matsumoto and KI Nakayama. A ubiquitin-like protein encoded by the "noncoding" RNA TINCR promotes keratinocyte proliferation and wound healing. PLoS Genet, 17:e1009686, 2021. DOI:1371/journal.pgen.1009686

  9. WS Kong, N Tsuyama, H Inoue, Y Guo, S Mokuda, A Nobukiyo, N Nakatani, F Yamaide, T Nakano, Y Kohno, K Ikeda, Y Nakanishi, H Ohno, M Arita, N Shimojo and M Kanno. Long-chain saturated fatty acids in breast milk are associated with the pathogenesis of atopic dermatitis via induction of inflammatory ILC3s. Sci Rep, 11:13109, 2021. DOI:1038/s41598-021-92282-0

  10. S Huang and T Yasuda. Pathologically Relevant Mouse Models for Epstein-Barr Virus-Associated B Cell Lymphoma. Front Immunol, 12:639844, 2021. DOI:3389/fimmu.2021.639844

 

  1. 2020
  2. K Yoshioka, Y Kitajima, N Okazaki, K Chiba, A Yonekura and Y Ono. A Modified Pre-plating Method for High-Yield and High-Purity Muscle Stem Cell Isolation From Human/Mouse Skeletal Muscle Tissues. Front Cell Dev Biol, 8:793, 2020. DOI:3389/fcell.2020.00793

  3. Y Yang, S Nagai, S Kang, Y Xia, Y Kawano, K Miyake, H Karasuyama and M Azuma. Tolerogenic properties of CD206+ macrophages appeared in the sublingual mucosa after repeated antigen-painting. Int Immunol, 32:509-518, 2020. DOI:1093/intimm/dxaa014

  4. Y Tsuchiya, Y Kitajima, H Masumoto and Y Ono. Damaged Myofiber-Derived Metabolic Enzymes Act as Activators of Muscle Satellite Cells. Stem Cell Reports, 15:926-940, 2020. DOI:1016/j.stemcr.2020.08.002

  5. T Sommermann, T Yasuda, J Ronen, T Wirtz, T Weber, U Sack, R Caeser, J Zhang, X Li, VT Chu, A Jauch, K Unger, DJ Hodson, A Akalin and K Rajewsky. Functional interplay of Epstein-Barr virus oncoproteins in a mouse model of B cell lymphomagenesis. Proc Natl Acad Sci U S A, 117:14421-14432, 2020. DOI:1073/pnas.1921139117

  6. S Osana, Y Kitajima, N Suzuki, Y Xu, K Murayama and R Nagatomi. siRNA knockdown of alanine aminopeptidase impairs myoblast proliferation and differentiation. Exp Cell Res, 397:112337, 2020. DOI:1016/j.yexcr.2020.112337

  7. H Ono, N Suzuki, SI Kanno, G Kawahara, R Izumi, T Takahashi, Y Kitajima, S Osana, N Nakamura, T Akiyama, K Ikeda, T Shijo, S Mitsuzawa, R Nagatomi, N Araki, A Yasui, H Warita, YK Hayashi, K Miyake and M Aoki. AMPK Complex Activation Promotes Sarcolemmal Repair in Dysferlinopathy. Mol Ther, 28:1133-1153, 2020. DOI:1016/j.ymthe.2020.02.006

  8. Y Kitajima, K Yoshioka and N Suzuki. The ubiquitin-proteasome system in regulation of the skeletal muscle homeostasis and atrophy: from basic science to disorders. J Physiol Sci, 70:40, 2020. DOI:1186/s12576-020-00768-9

  9. Y Kitajima, N Suzuki, K Yoshioka, R Izumi, M Tateyama, Y Tashiro, R Takahashi, M Aoki and Y Ono. Inducible Rpt3, a Proteasome Component, Knockout in Adult Skeletal Muscle Results in Muscle Atrophy. Front Cell Dev Biol, 8:859, 2020. DOI:3389/fcell.2020.00859

 

  1. 1997-2019
  2. S Yoshikawa, M Oh-Hora, R Hashimoto, T Nagao, L Peters, M Egawa, T Ohta, K Miyake, T Adachi, Y Kawano, Y Yamanishi and H Karasuyama. Pivotal role of STIM2, but not STIM1, in IL-4 production by IL-3-stimulated murine basophils. Sci Signal, 12:10.1126/scisignal.aav2060, 2019. DOI:1126/scisignal.aav2060

  3. T Nagao, Y Yamanishi, K Miyake, M Teranishi, S Takahashi, S Yoshikawa, Y Kawano and H Karasuyama. Aggregation makes a protein allergenic at the challenge phase of basophil-mediated allergy in mice. Int Immunol, 31:41-49, 2019. DOI:1093/intimm/dxy062

  4. K Imami and T Yasuda. Measuring Protein Synthesis during Cell Cycle by Azidohomoalanine (AHA) Labeling and Flow Cytometric Analysis. Bio Protoc, 9:e3215, 2019. DOI:21769/BioProtoc.3215

  5. T Akiyama, N Suzuki, M Ishikawa, K Fujimori, T Sone, J Kawada, R Funayama, F Fujishima, S Mitsuzawa, K Ikeda, H Ono, T Shijo, S Osana, M Shirota, T Nakagawa, Y Kitajima, A Nishiyama, R Izumi, S Morimoto, Y Okada, T Kamei, M Nishida, M Nogami, S Kaneda, Y Ikeuchi, H Mitsuhashi, K Nakayama, T Fujii, H Warita, H Okano and M Aoki. Aberrant axon branching via Fos-B dysregulation in FUS-ALS motor neurons. EBioMedicine, 45:362-378, 2019. DOI:1016/j.ebiom.2019.06.013

  6. Y Tabakawa, T Ohta, S Yoshikawa, EJ Robinson, K Yamaji, K Ishiwata, Y Kawano, K Miyake, Y Yamanishi, H Ohtsu, T Adachi, N Watanabe, H Kanuka and H Karasuyama. Histamine Released From Skin-Infiltrating Basophils but Not Mast Cells Is Crucial for Acquired Tick Resistance in Mice. Front Immunol, 9:1540, 2018. DOI:3389/fimmu.2018.01540

  7. T Shijo, H Warita, N Suzuki, Y Kitajima, K Ikeda, T Akiyama, H Ono, S Mitsuzawa, A Nishiyama, R Izumi and M Aoki. Aberrant astrocytic expression of chondroitin sulfate proteoglycan receptors in a rat model of amyotrophic lateral sclerosis. J Neurosci Res, 96:222-233, 2018. DOI:1002/jnr.24127

  8. T Shijo, H Warita, N Suzuki, K Ikeda, S Mitsuzawa, T Akiyama, H Ono, A Nishiyama, R Izumi, Y Kitajima and M Aoki. Antagonizing bone morphogenetic protein 4 attenuates disease progression in a rat model of amyotrophic lateral sclerosis. Exp Neurol, 307:164-179, 2018. DOI:1016/j.expneurol.2018.06.009

  9. G Petkau, Y Kawano, I Wolf, M Knoll and F Melchers. MiR221 promotes precursor B-cell retention in the bone marrow by amplifying the PI3K-signaling pathway in mice. Eur J Immunol, 48:975-989, 2018. DOI:1002/eji.201747354

  10. Y Kitajima, N Suzuki, A Nunomiya, S Osana, K Yoshioka, Y Tashiro, R Takahashi, Y Ono, M Aoki and R Nagatomi. The Ubiquitin-Proteasome System Is Indispensable for the Maintenance of Muscle Stem Cells. Stem Cell Reports, 11:1523-1538, 2018. DOI:1016/j.stemcr.2018.10.009

  11. Y Kitajima and Y Ono. Visualization of PAX7 protein dynamics in muscle satellite cells in a YFP knock-in-mouse line. Skelet Muscle, 8:26, 2018. DOI:1186/s13395-018-0174-x

  12. Y Kawano, G Petkau, C Stehle, P Durek, GA Heinz, K Tanimoto, H Karasuyama, MF Mashreghi, C Romagnani and F Melchers. Stable lines and clones of long-term proliferating normal, genetically unmodified murine common lymphoid progenitors. Blood, 131:2026-2035, 2018. DOI:1182/blood-2017-09-805259

  13. H Karasuyama, K Miyake, S Yoshikawa, Y Kawano and Y Yamanishi. How do basophils contribute to Th2 cell differentiation and allergic responses? Int Immunol, 30:391-396, 2018. DOI:1093/intimm/dxy026

  14. K Imami, M Milek, B Bogdanow, T Yasuda, N Kastelic, H Zauber, Y Ishihama, M Landthaler and M Selbach. Phosphorylation of the Ribosomal Protein RPL12/uL11 Affects Translation during Mitosis. Mol Cell, 72:84-98 e89, 2018. DOI:1016/j.molcel.2018.08.019

  15. VM Ho, N Hirohashi, WS Kong, G Yun, K Ota, J Itai, S Yamaga, K Suzuki, K Tanigawa, M Kanno and N Shime. Sera from Septic Patients Contain the Inhibiting Activity of the Extracellular ATP-Dependent Inflammasome Pathway. Tohoku J Exp Med, 245:193-204, 2018. DOI:1620/tjem.245.193

  16. A Harada, K Maehara, Y Ono, H Taguchi, K Yoshioka, Y Kitajima, Y Xie, Y Sato, T Iwasaki, J Nogami, S Okada, T Komatsu, Y Semba, T Takemoto, H Kimura, H Kurumizaka and Y Ohkawa. Histone H3.3 sub-variant H3mm7 is required for normal skeletal muscle regeneration. Nat Commun, 9:1400, 2018. DOI:1038/s41467-018-03845-1

  17. S Fujimaki, D Seko, Y Kitajima, K Yoshioka, Y Tsuchiya, S Masuda and Y Ono. Notch1 and Notch2 Coordinately Regulate Stem Cell Function in the Quiescent and Activated States of Muscle Satellite Cells. Stem Cells, 36:278-285, 2018. DOI:1002/stem.2743

  18. J Tornack, Y Kawano, N Garbi, GJ Hammerling, F Melchers and M Tsuneto. Flt3 ligand-eGFP-reporter expression characterizes functionally distinct subpopulations of CD150(+) long-term repopulating murine hematopoietic stem cells. Eur J Immunol, 47:1477-1487, 2017. DOI:1002/eji.201646730

  19. T Ohta, S Yoshikawa, Y Tabakawa, K Yamaji, K Ishiwata, H Shitara, C Taya, M Oh-Hora, Y Kawano, K Miyake, Y Yamanishi, H Yonekawa, N Watanabe, H Kanuka and H Karasuyama. Skin CD4(+) Memory T Cells Play an Essential Role in Acquired Anti-Tick Immunity through Interleukin-3-Mediated Basophil Recruitment to Tick-Feeding Sites. Front Immunol, 8:1348, 2017. DOI:3389/fimmu.2017.01348

  20. A Nunomiya, J Shin, Y Kitajima, T Dan, T Miyata and R Nagatomi. Activation of the hypoxia-inducible factor pathway induced by prolyl hydroxylase domain 2 deficiency enhances the effect of running training in mice. Acta Physiol, 220:99-112, 2017. DOI:1111/apha.12751

  21. Y Kawano, G Petkau, I Wolf, J Tornack and F Melchers. IL-7 and immobilized Kit-ligand stimulate serum- and stromal cell-free cultures of precursor B-cell lines and clones. Eur J Immunol 47:206-212, 2017. DOI:1002/eji.201646677

  22. T Wirtz, T Weber, S Kracker, T Sommermann, K Rajewsky and T Yasuda. Mouse model for acute Epstein-Barr virus infection. Proc Natl Acad Sci U S A, 113:13821-13826, 2016. DOI:1073/pnas.1616574113

  23. A Uruno, Y Yagishita, F Katsuoka, Y Kitajima, A Nunomiya, R Nagatomi, J Pi, SS Biswal and M Yamamoto. Nrf2-Mediated Regulation of Skeletal Muscle Glycogen Metabolism. Mol Cell Biol, 36:1655-1672, 2016. DOI:1128/MCB.01095-15

  24. H Shinohara, T Yasuda and T Kurosaki. TAK1 adaptor proteins, TAB2 and TAB3, link the signalosome to B-cell receptor-induced IKK activation. FEBS Lett, 590:3264-3269, 2016. DOI:1002/1873-3468.12342

  25. J Shin, A Nunomiya, Y Kitajima, T Dan, T Miyata and R Nagatomi. Prolyl hydroxylase domain 2 deficiency promotes skeletal muscle fiber-type transition via a calcineurin/NFATc1-dependent pathway. Skelet Muscle, 6:5, 2016. DOI:1186/s13395-016-0079-5

  26. DJ Klionsky, ... Y Kitajima, ... and SM Zughaier. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy, 12:1-222, 2016. DOI:1080/15548627.2015.1100356

  27. Y Kitajima, S Ogawa and Y Ono. Visualizing the Functional Heterogeneity of Muscle Stem Cells. Methods Mol Biol, 1516:183-193, 2016. DOI:1007/7651_2016_349

  28. E Ishikawa, H Kosako, T Yasuda, M Ohmuraya, K Araki, T Kurosaki, T Saito and S Yamasaki. Protein kinase D regulates positive selection of CD4(+) thymocytes through phosphorylation of SHP-1. Nat Commun, 7:12756, 2016. DOI:1038/ncomms12756

  29. E Derudder, S Herzog, V Labi, T Yasuda, K Kochert, M Janz, A Villunger, M Schmidt-Supprian and K Rajewsky. Canonical NF-kappaB signaling is uniquely required for the long-term persistence of functional mature B cells. Proc Natl Acad Sci U S A, 113:5065-5070, 2016. DOI:1073/pnas.1604529113

  30. S Cho, CJ Wu, T Yasuda, LO Cruz, AA Khan, LL Lin, DT Nguyen, M Miller, HM Lee, ML Kuo, DH Broide, K Rajewsky, AY Rudensky and LF Lu. miR-23 approximately 27 approximately 24 clusters control effector T cell differentiation and function. J Exp Med, 213:235-249, 2016. DOI:1084/jem.20150990

  31. T Yasuda. 2015. MAP kinase cascades in antigen receptor signaling and physiology. Current Topics in Microbiology and Immunology, 393, 2015. DOI:1007/82_2015_481

  32. M Yamaya, Y Shimotai, Y Hatachi, N Lusamba Kalonji, Y Tando, Y Kitajima, K Matsuo, H Kubo, R Nagatomi, S Hongo, M Homma and H Nishimura. The serine protease inhibitor camostat inhibits influenza virus replication and cytokine production in primary cultures of human tracheal epithelial cells. Pulm Pharmacol Ther, 33:66-74, 2015. DOI:1016/j.pupt.2015.07.001

  33. S Sander, VT Chu, T Yasuda, A Franklin, R Graf, DP Calado, S Li, K Imami, M Selbach, M Di Virgilio, L Bullinger and K Rajewsky. PI3 Kinase and FOXO1 Transcription Factor Activity Differentially Control B Cells in the Germinal Center Light and Dark Zones. Immunity, 43:1075-1086, 2015. DOI:1016/j.immuni.2015.10.021

  34. Y Murakawa, M Hinz, J Mothes, A Schuetz, M Uhl, E Wyler, T Yasuda, G Mastrobuoni, CC Friedel, L Dolken, S Kempa, M Schmidt-Supprian, N Bluthgen, R Backofen, U Heinemann, J Wolf, C Scheidereit and M Landthaler. RC3H1 post-transcriptionally regulates A20 mRNA and modulates the activity of the IKK/NF-kappaB pathway. Nat Commun, 6:7367, 2015. DOI:1038/ncomms8367

  35. S Mokuda, T Miyazaki, Y Ito, S Yamasaki, H Inoue, Y Guo, WS Kong, M Kanno, K Takasugi, E Sugiyama and J Masumoto. The proto-oncogene survivin splice variant 2B is induced by PDGF and leads to cell proliferation in rheumatoid arthritis fibroblast-like synoviocytes. Sci Rep, 5:9795, 2015. DOI:1038/srep09795

  36. L LiHua, S Yoshikawa, T Ohta, K Horiguchi, Y Kawano, H Ohtsu, Y Yamanishi and H Karasuyama. Large particulate allergens can elicit mast cell-mediated anaphylaxis without exit from blood vessels as efficiently as do small soluble allergens. Biochem Biophys Res Commun, 467:70-75, 2015. DOI:1016/j.bbrc.2015.09.120

  37. S Yasukawa, Y Miyazaki, C Yoshii, M Nakaya, N Ozaki, S Toda, E Kuroda, K Ishibashi, T Yasuda, Y Natsuaki, F Mi-ichi, E Iizasa, T Nakahara, M Yamazaki, K Kabashima, Y Iwakura, T Takai, T Saito, T Kurosaki, B Malissen, N Ohno, M Furue, H Yoshida and H Hara. An ITAM-Syk-CARD9 signalling axis triggers contact hypersensitivity by stimulating IL-1 production in dendritic cells. Nat Commun, 5:3755, 2014. DOI:1038/ncomms4755

  38. H Shinohara, M Behar, K Inoue, M Hiroshima, T Yasuda, T Nagashima, S Kimura, H Sanjo, S Maeda, N Yumoto, S Ki, S Akira, Y Sako, A Hoffmann, T Kurosaki and M Okada-Hatakeyama. Positive feedback within a kinase signaling complex functions as a switch mechanism for NF-kappaB activation. Science, 344:760-764, 2014. DOI:1126/science.1250020

  39. Y Kitajima, Y Tashiro, N Suzuki, H Warita, M Kato, M Tateyama, R Ando, R Izumi, M Yamazaki, M Abe, K Sakimura, H Ito, M Urushitani, R Nagatomi, R Takahashi and M Aoki. Proteasome dysfunction induces muscle growth defects and protein aggregation. J Cell Sci, 127:5204-5217, 2014. DOI:1242/jcs.150961

  40. T Yasuda, T Wirtz, B Zhang, T Wunderlich, M Schmidt-Supprian, T Sommermann and K Rajewsky. Studying Epstein-Barr virus pathologies and immune surveillance by reconstructing EBV infection in mice. Cold Spring Harb Symp Quant Biol, 78:259-263, 2013. DOI:1101/sqb.2013.78.020222

  41. K Obata-Ninomiya, K Ishiwata, H Tsutsui, Y Nei, S Yoshikawa, Y Kawano, Y Minegishi, N Ohta, N Watanabe, H Kanuka and H Karasuyama. The skin is an important bulwark of acquired immunity against intestinal helminths. J Exp Med, 210:2583-2595, 2013. DOI:1084/jem.20130761

  42. A Farmawati, Y Kitajima, T Nedachi, M Sato, M Kanzaki and R Nagatomi. Characterization of contraction-induced IL-6 up-regulation using contractile C2C12 myotubes. Endocr J, 60:137-147, 2013. DOI:1507/endocrj.ej12-0316

  43. M Egawa, K Mukai, S Yoshikawa, M Iki, N Mukaida, Y Kawano, Y Minegishi and H Karasuyama. Inflammatory monocytes recruited to allergic skin acquire an anti-inflammatory M2 phenotype via basophil-derived interleukin-4. Immunity, 38:570-580, 2013. DOI:1016/j.immuni.2012.11.014

  44. B Zhang, S Kracker, T Yasuda, S Casola, M Vanneman, C Homig-Holzel, Z Wang, E Derudder, S Li, T Chakraborty, SE Cotter, S Koyama, T Currie, GJ Freeman, JL Kutok, SJ Rodig, G Dranoff and K Rajewsky. Immune surveillance and therapy of lymphomas driven by Epstein-Barr virus protein LMP1 in a mouse model. Cell, 148:739-751, 2012. DOI:1016/j.cell.2011.12.031

  45. H Ogawa, K Mukai, Y Kawano, Y Minegishi and H Karasuyama. Th2-inducing cytokines IL-4 and IL-33 synergistically elicit the expression of transmembrane TNF-alpha on macrophages through the autocrine action of IL-6. Biochem Biophys Res Commun, 420:114-118, 2012. DOI:1016/j.bbrc.2012.02.124

  46. Y Kawano, R Ouchida, JY Wang, S Yoshikawa, M Yamamoto, D Kitamura and H Karasuyama. A novel mechanism for the autonomous termination of pre-B cell receptor expression via induction of lysosome-associated protein transmembrane 5. Mol Cell Biol, 32:4462-4471, 2012. DOI:1128/MCB.00531-12

  47. T Yasuda, K Kometani, N Takahashi, Y Imai, Y Aiba and T Kurosaki. ERKs induce expression of the transcriptional repressor Blimp-1 and subsequent plasma cell differentiation. Sci Signal, 4:ra25, 2011. DOI:1126/scisignal.2001592

  48. H Yamagishi, Y Mochizuki, T Hamakubo, K Obata, T Ugajin, S Sato, Y Kawano, Y Minegishi and H Karasuyama. Basophil-derived mouse mast cell protease 11 induces microvascular leakage and tissue edema in a mast cell-independent manner. Biochem Biophys Res Commun, 415:709-713, 2011. DOI:1016/j.bbrc.2011.10.150

  49. H Nishikado, K Mukai, Y Kawano, Y Minegishi and H Karasuyama. NK cell-depleting anti-asialo GM1 antibody exhibits a lethal off-target effect on basophils in vivo. J Immunol, 186:5766-5771, 2011. DOI:4049/jimmunol.1100370

  50. T Wada, K Ishiwata, H Koseki, T Ishikura, T Ugajin, N Ohnuma, K Obata, R Ishikawa, S Yoshikawa, K Mukai, Y Kawano, Y Minegishi, H Yokozeki, N Watanabe and H Karasuyama. Selective ablation of basophils in mice reveals their nonredundant role in acquired immunity against ticks. J Clin Invest, 120:2867-2875, 2010. DOI:1172/JCI42680

  51. S Kuchen, W Resch, A Yamane, N Kuo, Z Li, T Chakraborty, L Wei, A Laurence, T Yasuda, S Peng, J Hu-Li, K Lu, W Dubois, Y Kitamura, N Charles, HW Sun, S Muljo, PL Schwartzberg, WE Paul, J O'Shea, K Rajewsky and R Casellas. Regulation of microRNA expression and abundance during lymphopoiesis. Immunity, 32:828-839, 2010. DOI:1016/j.immuni.2010.05.009

  52. R Ishikawa, Y Tsujimura, K Obata, Y Kawano, Y Minegishi and H Karasuyama. IgG-mediated systemic anaphylaxis to protein antigen can be induced even under conditions of limited amounts of antibody and antigen. Biochem Biophys Res Commun, 402:742-746, 2010. DOI:1016/j.bbrc.2010.10.098

  53. S Yoshikawa, Y Kawano, Y Minegishi and H Karasuyama. The skewed heavy-chain repertoire in peritoneal B-1 cells is predetermined by the selection via pre-B cell receptor during B cell ontogeny in the fetal liver. Int Immunol, 21:43-52, 2009. DOI:1093/intimm/dxn122

  54. T Ugajin, T Kojima, K Mukai, K Obata, Y Kawano, Y Minegishi, Y Eishi, H Yokozeki and H Karasuyama. Basophils preferentially express mouse Mast Cell Protease 11 among the mast cell tryptase family in contrast to mast cells. J Leukoc Biol, 86:1417-1425, 2009. DOI:1189/jlb.0609400

  55. T Yasuda, H Sanjo, G Pages, Y Kawano, H Karasuyama, J Pouyssegur, M Ogata and T Kurosaki. Erk kinases link pre-B cell receptor signaling to transcriptional events required for early B cell expansion. Immunity, 28:499-508, 2008. DOI:1016/j.immuni.2008.02.015

  56. T Yasuda and T Kurosaki. Regulation of lymphocyte fate by Ras/ERK signals. Cell Cycle, 7:3634-3640, 2008. DOI:4161/cc.7.23.7103

  57. Y Tsujimura, K Obata, K Mukai, H Shindou, M Yoshida, H Nishikado, Y Kawano, Y Minegishi, T Shimizu and H Karasuyama. Basophils play a pivotal role in immunoglobulin-G-mediated but not immunoglobulin-E-mediated systemic anaphylaxis. Immunity, 28:581-589, 2008. DOI:1016/j.immuni.2008.02.008

  58. T Hosooka, T Noguchi, K Kotani, T Nakamura, H Sakaue, H Inoue, W Ogawa, K Tobimatsu, K Takazawa, M Sakai, Y Matsuki, R Hiramatsu, T Yasuda, MA Lazar, Y Yamanashi and M Kasuga. Dok1 mediates high-fat diet-induced adipocyte hypertrophy and obesity through modulation of PPAR-gamma phosphorylation. Nat Med, 14:188-193, 2008. DOI:1038/nm1706

  59. T Yasuda, K Bundo, A Hino, K Honda, A Inoue, M Shirakata, M Osawa, T Tamura, H Nariuchi, H Oda, T Yamamoto and Y Yamanashi. Dok-1 and Dok-2 are negative regulators of T cell receptor signaling. Int Immunol, 19:487-495, 2007. DOI:1093/intimm/dxm015

  60. K Obata, K Mukai, Y Tsujimura, K Ishiwata, Y Kawano, Y Minegishi, N Watanabe and H Karasuyama. Basophils are essential initiators of a novel type of chronic allergic inflammation. Blood, 110:913-920, 2007. DOI:1182/blood-2007-01-068718

  61. Y Matsubara, I Kawasaki, S Urushiyama, T Yasuda, M Shirakata, Y Iino, H Shibuya and Y Yamanashi. The adaptor-like protein ROG-1 is required for activation of the Ras-MAP kinase pathway and meiotic cell cycle progression in Caenorhabditis elegans. Genes Cells, 12:407-420, 2007. DOI:1111/j.1365-2443.2007.01061.x

  62. A Inoue, T Yasuda, T Yamamoto and Y Yamanashi. Dok-1 is a positive regulator of IL-4 signalling and IgE response. J Biochem, 142:257-263, 2007. DOI:1093/jb/mvm127

  63. M Yamamoto, K Hayashi, T Nojima, Y Matsuzaki, Y Kawano, H Karasuyama, R Goitsuka and D Kitamura. BASH-novel PKC-Raf-1 pathway of pre-BCR signaling induces kappa gene rearrangement. Blood, 108:2703-2711, 2006. DOI:1182/blood-2006-05-024968

  64. Y Kawano, S Yoshikawa, Y Minegishi and H Karasuyama. Pre-B cell receptor assesses the quality of IgH chains and tunes the pre-B cell repertoire by delivering differential signals. J Immunol, 177:2242-2249, 2006. DOI:4049/jimmunol.177.4.2242

  65. M Honma, O Higuchi, M Shirakata, T Yasuda, H Shibuya, S Iemura, T Natsume and Y Yamanashi. Dok-3 sequesters Grb2 and inhibits the Ras-Erk pathway downstream of protein-tyrosine kinases. Genes Cells, 11:143-151, 2006. DOI:1111/j.1365-2443.2006.00926.x

  66. H Shinohara, T Yasuda, Y Aiba, H Sanjo, M Hamadate, H Watarai, H Sakurai and T Kurosaki. PKC beta regulates BCR-mediated IKK activation by facilitating the interaction between TAK1 and CARMA1. J Exp Med, 202:1423-1431, 2005. DOI:1084/jem.20051591

  67. H Shinohara, A Inoue, N Toyama-Sorimachi, Y Nagai, T Yasuda, H Suzuki, R Horai, Y Iwakura, T Yamamoto, H Karasuyama, K Miyake and Y Yamanashi. Dok-1 and Dok-2 are negative regulators of lipopolysaccharide-induced signaling. J Exp Med, 201:333-339, 2005. DOI:1084/jem.20041817

  68. Y Kawano, S Yoshikawa, Y Minegishi and H Karasuyama. Selection of stereotyped VH81X-microH chains via pre-B cell receptor early in ontogeny and their conservation in adults by marginal zone B cells. Int Immunol, 17:857-867, 2005. DOI:1093/intimm/dxh265

  69. Y Katakura, K Yoshizaki, T Yasuda, T Tsunematsu, N Uehara, T Miura, T Fujiki and S Shirahata. Functional impairment of telomerase in sublines derived from human lung adenocarcinoma exposed to mild oxidative stress. Biochem Biophys Res Commun, 334:450-459, 2005. DOI:1016/j.bbrc.2005.06.109

  70. T Yasuda and T Yamamoto. Analysis of B-cell signaling using DT40 B-cell line. Methods Mol Biol, 271:261-270, 2004. DOI:1385/1-59259-796-3:261

  71. T Yasuda, M Shirakata, A Iwama, A Ishii, Y Ebihara, M Osawa, K Honda, H Shinohara, K Sudo, K Tsuji, H Nakauchi, Y Iwakura, H Hirai, H Oda, T Yamamoto and Y Yamanashi. Role of Dok-1 and Dok-2 in myeloid homeostasis and suppression of leukemia. J Exp Med, 200:1681-1687, 2004. DOI:1084/jem.20041247

  72. H Shinohara, T Yasuda and Y Yamanashi. Dok-1 tyrosine residues at 336 and 340 are essential for the negative regulation of Ras-Erk signalling, but dispensable for rasGAP-binding. Genes Cells, 9:601-607, 2004. DOI:1111/j.1356-9597.2004.00748.x

  73. K Tsuchiya, Y Kawano, T Kojima, K Nagata, T Takao, M Okada, H Shinohara, K Maki, N Toyama-Sorimachi, N Miyasaka, M Watanabe and H Karasuyama. Molecular cloning and characterization of TPP36 and its isoform TPP32, novel substrates of Abl tyrosine kinase. FEBS Lett, 537:203-209, 2003. DOI:1016/s0014-5793(03)00127-3

  74. K Yokoyama, IH Su Ih, T Tezuka, T Yasuda, K Mikoshiba, A Tarakhovsky and T Yamamoto. BANK regulates BCR-induced calcium mobilization by promoting tyrosine phosphorylation of IP(3) receptor. EMBO J, 21:83-92, 2002. DOI:1093/emboj/21.1.83

  75. T Yasuda, T Tezuka, A Maeda, T Inazu, Y Yamanashi, H Gu, T Kurosaki and T Yamamoto. Cbl-b positively regulates Btk-mediated activation of phospholipase C-gamma2 in B cells. J Exp Med, 196:51-63, 2002. DOI:1084/jem.20020068

  76. M Magari, T Sawatari, Y Kawano, M Cascalho, M Wabl, N Kanayama, M Hikida and H Ohmori. Contribution of light chain rearrangement in peripheral B cells to the generation of high-affinity antibodies. Eur J Immunol, 32:957-966, 2002. DOI:1002/1521-4141(200204)32:4<957::AID-IMMU957>3.0.CO;2-A

  77. T Yasuda, A Maeda, M Kurosaki, T Tezuka, K Hironaka, T Yamamoto and T Kurosaki. Cbl suppresses B cell receptor-mediated phospholipase C (PLC)-gamma2 activation by regulating B cell linker protein-PLC-gamma2 binding. J Exp Med, 191:641-650, 2000. DOI:1084/jem.191.4.641

  78. Y Katakura, K Yamamoto, O Miyake, T Yasuda, N Uehara, E Nakata, S Kawamoto and S Shirahata. Bidirectional regulation of telomerase activity in a subline derived from human lung adenocarcinoma. Biochem Biophys Res Commun, 237:313-317, 1997. DOI:1006/bbrc.1997.7104